Suboptimal medication use and mortality in an older adult community-based cohort: results from the Hispanic EPESE Study

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
David V EspinoKyriakos Markides

Abstract

Numerous methods have been used to evaluate medication management quality in older adults; however, their predictive validities are unknown. Major medication quality indicators include polypharmacy, drug-drug interactions, and inappropriate medication use. To date, no study has attempted to evaluate the three approaches systematically or the effect of each approach on mortality in a Hispanic population. Our objective was to evaluate the relationship between polypharmacy, drug-drug interactions, and inappropriate medication use on the mortality of a community-based population of Mexican American older adults. We used a life table survival analysis of a longitudinal survey of a representative sample of 3,050 older Mexican Americans of whom 1,823 were taking prescription and over-the-counter medications. After adjustment for relevant covariates, use of more than four different medications (polypharmacy) was independently associated with mortality. The presence of major drug interactions and the use of inappropriate medications were not significantly associated with mortality in our study sample. Polypharmacy (>4 medications) is significantly associated with mortality in Mexican American older adults. This community-based study is ...Continue Reading

References

Oct 1, 1985·Journal of the American Geriatrics Society·G G Fillenbaum
May 1, 1980·Archives of Internal Medicine·M J GillL K Harding
Feb 1, 1993·Annals of Internal Medicine·M C Creditor
Mar 21, 1998·Lancet·D P PhillipsL M Glynn
Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Jul 29, 1998·European Journal of Clinical Pharmacology·L BjerrumJ Kragstrup
Jun 24, 1999·Journal of Clinical Pharmacy and Therapeutics·E Tanaka
Aug 12, 1999·Journal of the American Geriatrics Society·A G GoldenM A Silverman
Oct 18, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J H FlahertyJ E Morley
Nov 10, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·M I LangdorfM M Hart
Apr 12, 2001·Journal of the American Pharmaceutical Association : APhA·F R Ernst, A J Grizzle
Oct 13, 2001·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·J PhillipsC Pamer
Mar 27, 2002·European Heart Journal·B M Buckley
Apr 30, 2002·The Annals of Pharmacotherapy·Anita KennerfalkSaga Johansson
Apr 18, 2003·The New England Journal of Medicine·Tejal K GandhiDavid W Bates
Aug 19, 2003·The Annals of Pharmacotherapy·Mukaila A RajiJames S Goodwin
May 6, 2004·Annals of Internal Medicine·Takahiro HigashiNeil S Wenger

❮ Previous
Next ❯

Citations

Oct 14, 2011·Journal of General Internal Medicine·Adam A PowellHanna E Bloomfield
Jun 7, 2013·Drugs & Aging·E Jennifer EdelmanAmy C Justice
Nov 20, 2012·Journal of Nutrition in Gerontology and Geriatrics·Roschelle Heuberger
Aug 17, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Huai Yong Cheng
Jun 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lily L SomwaruAnne R Cappola
Apr 27, 2010·The Oncologist·Ronald J MaggioreArti Hurria
Oct 31, 2007·Expert Opinion on Drug Safety·Joel A SalazarMridula Nair
Feb 26, 2016·Archives of Gerontology and Geriatrics·Maarten WautersMajda Azermai
Jul 4, 2012·The American Journal of Geriatric Pharmacotherapy·Nariman MansurYichayaou Beloosesky
Jul 14, 2010·The American Journal of Geriatric Pharmacotherapy·Victor CrentsilLinda P Fried
Jan 9, 2008·The American Journal of Geriatric Pharmacotherapy·Emily R HajjarJoseph T Hanlon
Oct 20, 2007·Journal of the American Geriatrics Society·Giampiero MazzagliaMauro Di Bari
Nov 26, 2015·Health Services Research·Chi-Chen Chen, Shou-Hsia Cheng
Dec 18, 2014·Journal of the American Geriatrics Society·Terri R FriedDeanna K Martin
Jun 16, 2016·Journal of the American Geriatrics Society·Agata SchlesingerYichayaou Beloosesky
Apr 10, 2016·British Journal of Clinical Pharmacology·Tim JohanssonAndreas Sönnichsen
Oct 12, 2016·Geriatrics & Gerontology International·G Blair SarbackerKyriakos A Markides
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre SoubeyranMuriel Rainfray
Nov 19, 2009·The Annals of Pharmacotherapy·Janne MoenLena Ring
Nov 26, 2009·Drugs & Aging·Johanna JyrkkäSirpa Hartikainen
Mar 23, 2017·Scandinavian Journal of Medicine & Science in Sports·K A VolaklisC Meisinger
Dec 27, 2017·Primary Health Care Research & Development·Andrea C SchöpfAndy Maun
Mar 5, 2018·International Journal of Clinical Pharmacy·Eiji KoseHiroyuki Hayashi
Sep 21, 2011·Geriatrics & Gerontology International·Tuck Yean YongCampbell Henry Thompson
Apr 2, 2020·BMC Research Notes·Takeshi Horii, Koichiro Atsuda
Feb 22, 2007·The Annals of Pharmacotherapy·Elda Jano, Rajender R Aparasu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Clinical Pharmacology
G ZiereB H Ch Stricker
JAMA : the Journal of the American Medical Association
David W KaufmanAllen A Mitchell
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
L P FriedCardiovascular Health Study Collaborative Research Group
© 2021 Meta ULC. All rights reserved