Suboptimal non-inflammatory concentrations of haptens may elicit a contact sensitivity reaction when used as a mix

Contact Dermatitis
M KrastevaJ F Nicolas

Abstract

Contact dermatitis is a cutaneous inflammatory reaction mediated by hapten-specific T cells. We used a murine model to investigate the contact sensitivity reaction elicited by different concentrations (optimal and suboptimal) of the haptens DNFB and oxazolone applied singly or in combination. The simultaneous application of DNFB and oxazolone at optimal concentrations (0.2% and 0.4% respectively) did not significantly increase the ear swelling response induced by each of the allergens when applied singly. No contact sensitivity response was observed when the haptens were tested individually at subthreshold concentrations (0.05% and 0.1% respectively). However, mixing the 2 molecules at the same concentrations gave rise to a clinical contact sensitivity reaction. The simultaneous application of the haptens at a 2 x higher, but still suboptimal concentrations (0.1% and 0.2% respectively), elicited an inflammatory response that was significantly greater than the responses elicited by either of the haptens when applied separately. These results suggest that a "false-positive" reaction to a mix may reveal a genuine sensitization to the constituents.

References

May 1, 1990·The British Journal of Dermatology·J McLelland, S Shuster
Feb 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L BronaughJ L McCoy
Jan 1, 1995·Contact Dermatitis·J D Johansen, T Menné
Aug 1, 1993·The Journal of Investigative Dermatology·I Kurimoto, J W Streilein
Mar 1, 1996·The Journal of Experimental Medicine·K SteinbrinkE Macher

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Citations

Oct 15, 2009·Contact Dermatitis·Louise Arup FischerJeanne Duus Johansen
Dec 31, 1997·Contact Dermatitis·J Mitchell, H I Maibach
Jul 23, 1998·Journal of the American Academy of Dermatology·S M Wilkinson, R Burd
Jul 25, 2000·The Journal of Veterinary Medical Science·T KurotakiT Yoshikawa
Oct 7, 2010·Journal of Nutritional Science and Vitaminology·Reiko FujiwaraKei Sonoyama

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