Suboptimal UVA attenuation by broad spectrum sunscreens under outdoor solar conditions contributes to lifetime UVA burden.

Photodermatology, Photoimmunology & Photomedicine
Sergio G CoelhoAnant Agrawal

Abstract

Broad spectrum sunscreens with a sun protection factor (SPF) of 15 or greater are indicated to decrease the risk of skin cancer and early skin aging caused by the sun if used as directed with other sun protection measures. To determine whether sunscreen product performance is compromised under solar exposure and to test spectral uniformity of protection across the UVA spectrum, we tested broad spectrum sunscreens with a variety of active pharmaceutical ingredients (APIs) and in a variety of dosage forms. A cross-sectional market survey of 32 sunscreen drug products containing either organic or inorganic APIs with SPFs of 15, 30, 50, and 70 was tested. UV doses were delivered via natural sun in Silver Spring, Maryland between June and September of 2017. Of the 32 sunscreen drug products, 6 products failed to meet their broad spectrum claim under solar exposure. Using FDA's new proposal to strengthen sunscreen broad spectrum requirements, spectral uniformity based on the mean sunscreen absorbance of UVA1(340-400 nm)/UV (290-400 nm) indicated that ~40% of sunscreen drug products tested had suboptimal UVA protection. US consumers may unknowingly be receiving up to 36% more transmitted UVA when selecting between similarly labeled br...Continue Reading

References

Aug 21, 2001·The Journal of Investigative Dermatology·H MaierH Hönigsmann
Apr 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Taketsugu TadokoroVincent J Hearing
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Feb 28, 2007·BMC Dermatology·Helena GonzalezAnn-Marie Wennberg
Apr 7, 2007·International Journal of Cancer. Journal International Du Cancer·Philippe AutierJean-François Doré
Jul 26, 2008·Annals of Epidemiology·Leslie K DennisJulie A Coughlin
Oct 7, 2008·Journal of the American Academy of Dermatology·Steven Q WangUli Osterwalder
Jan 13, 2009·International Journal of Cosmetic Science·B Diffey
Apr 11, 2009·International Journal of Epidemiology·Yu-mei ChangJulia A Newton-Bishop
Dec 9, 2009·Pigment Cell & Melanoma Research·Sergio G Coelho, Vincent J Hearing
Mar 8, 2011·The British Journal of Dermatology·D L DamianG M Halliday
Oct 7, 2011·The Journal of Investigative Dermatology·Angela TewariAntony R Young
Jun 8, 2012·Nature Communications·Frances P NoonanEdward C De Fabo
Jul 24, 2012·Cell·Eran HodisLynda Chin
Jul 31, 2012·Nature Genetics·Michael KrauthammerRuth Halaban
Oct 2, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bibi PetersenHans Christian Wulf
Nov 30, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Angela TewariAntony R Young
Feb 18, 2016·JAMA Dermatology·Brian Diffey
Mar 10, 2016·Toxicologic Pathology·Douglas E Brash
Sep 1, 2016·JAMA Dermatology·Gery P GuyMeg Watson
May 7, 2019·JAMA : the Journal of the American Medical Association·Murali K MattaDavid G Strauss

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Citations

Oct 4, 2021·Photodermatology, Photoimmunology & Photomedicine·David Q AndrewsNneka Leiba

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