Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin.

Frontiers in Immunology
Elia Moreno CuberoDimitra Peppa

Abstract

Natural Killer (NK) cells play an important role in antiviral defense and their potent effector function identifies them as key candidates for immunotherapeutic interventions in chronic viral infections. Their remarkable functional agility is achieved by virtue of a wide array of germline-encoded inhibitory and activating receptors ensuring a self-tolerant and tunable repertoire. NK cell diversity is generated by a combination of factors including genetic determinants and infections/environmental factors, which together shape the NK cell pool and functional potential. Recently a genetic polymorphism at position -21 of HLA-B, which influences the supply of HLA-E binding peptides and availability of HLA-E for recognition by the inhibitory NK cell receptor NKG2A, was shown to have a marked influence on NK cell functionality in healthy human cytomegalovirus (HCMV) seronegative Caucasian individuals. In this study, -21 methionine (M)-expressing alleles supplying HLA-E binding peptides were largely poor ligands for inhibitory killer immunoglobulin-like receptors (KIRs), and a bias to NKG2A-mediated education of functionally-potent NK cells was observed. Here, we investigated the effect of this polymorphism on the phenotype and functi...Continue Reading

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Citations

Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Aljawharah AlrubayyiDimitra Peppa
Jan 29, 2021·Clinical & Translational Immunology·Martin R Goodier, Eleanor M Riley

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
genotyping
PCR
Flow Cytometry
FCS
ELISA

Software Mentioned

GraphPad
SPICE
Cytobank
VisNE
FlowJo
FlowSOM
Prism
TreeStar

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