Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis

Bulletin of Experimental Biology and Medicine
T E KononovaE G Churina

Abstract

The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.

References

Jun 28, 2008·Cellular & Molecular Immunology·Mei Yu PengBai Qing Li
Jan 22, 2011·Clinical & Developmental Immunology·Serena MeravigliaAngelo Martino
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arun T KamathClaire-Anne Siegrist

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