Subpopulations of cholinergic, GABAergic and glutamatergic neurons in the pedunculopontine nucleus contain calcium-binding proteins and are heterogeneously distributed.

The European Journal of Neuroscience
Cristina Martinez-GonzalezJuan Mena-Segovia

Abstract

Neurons in the pedunculopontine nucleus (PPN) are highly heterogeneous in their discharge properties, their neurochemical markers, their pattern of connectivity and the behavioural processes in which they participate. Three main transmitter phenotypes have been described, cholinergic, GABAergic and glutamatergic, and yet electrophysiological evidence suggests heterogeneity within these subtypes. To gain further insight into the molecular composition of these three populations in the rat, we investigated the pattern of expression of calcium binding proteins (CBPs) across distinct regions of the PPN and in relation to the presence of other neurochemical markers. Calbindin- and calretinin-positive neurons are as abundant as cholinergic neurons, and their expression follows a rostro-caudal gradient, whereas parvalbumin is expressed by a low number of neurons. We observed a high degree of expression of CBPs by GABAergic and glutamatergic neurons, with a large majority of calbindin- and calretinin-positive neurons expressing GAD or VGluT2 mRNA. Notably, CBP-positive neurons expressing GAD mRNA were more concentrated in the rostral PPN, whereas the caudal PPN was characterized by a higher density of CBP-positive neurons expressing VGl...Continue Reading

References

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Mar 1, 1990·Brain Research Bulletin·E Garcia-RillR D Skinner
Jun 1, 1987·Brain Research Bulletin·E Garcia-RillD J Woodward
Oct 21, 1985·Brain Research·R PochetJ L Pasteels
Dec 10, 1984·Brain Research·R D Skinner, E Garcia-Rill
Apr 29, 1982·Brain Research·R P BarberE Roberts
Dec 1, 1993·The Journal of Physiology·P S ChardR J Miller
Aug 1, 1996·Neuroscience Research·A ParentF Cicchetti
Aug 26, 2000·Brain : a Journal of Neurology·P A Pahapill, A M Lozano
Dec 7, 2000·Biophysical Journal·U V NägerlJ L Vergara
Aug 20, 2003·The European Journal of Neuroscience·Kazuya SaitohKaoru Takakusaki
Dec 4, 2003·The Journal of Comparative Neurology·Jochen F StaigerWerner Zuschratter
Mar 18, 2008·Brain Research Reviews·J Mena-SegoviaJ P Bolam
Apr 29, 2008·The Journal of Physiology·Juan Mena-SegoviaJ Paul Bolam
Mar 14, 2009·Neuroscience·S D Motts, B R Schofield
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soufiane Boucetta, Barbara E Jones
May 20, 2009·The International Journal of Biochemistry & Cell Biology·Aaron James Camp, Rajiv Wijesinghe
May 22, 2009·The Journal of Comparative Neurology·J Mena-SegoviaJ P Bolam
Jan 5, 2011·The European Journal of Neuroscience·Takako Kita, Hitoshi Kita
Apr 20, 2011·Frontiers in Neuroanatomy·Cristina Martinez-GonzalezJuan Mena-Segovia

❮ Previous
Next ❯

Citations

Aug 31, 2013·Experimental Brain Research·María Esther Olvera-CortésMiguel Angel López-Vázquez
May 28, 2013·Brain Structure & Function·Cristina Martinez-GonzalezJuan Mena-Segovia
Mar 8, 2016·Journal of Neural Transmission·Juan Mena-Segovia
Aug 16, 2014·Brain Structure & Function·Alexander C SuttonDamian S Shin
May 21, 2015·Brain Structure & Function·Joanna L ElsonIlse S Pienaar
Jul 9, 2016·Progress in Neurobiology·Philippe De DeurwaerdèreMark J Millan
Dec 10, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ilse S PienaarPhilip Winn
Aug 16, 2018·Bioinspiration & Biomimetics·Jacques Duysens, Arturo Forner-Cordero
Nov 20, 2015·Frontiers in Neural Circuits·Anne PetzoldJuan Mena-Segovia
Sep 26, 2020·Frontiers in Systems Neuroscience·Stephano J ChangBrian R Noga
May 15, 2018·Frontiers in Aging Neuroscience·Isobel T French, Kalai A Muthusamy
Feb 6, 2020·Frontiers in Pharmacology·Nicole Elaine ChambersChristopher Bishop
Mar 18, 2017·Neurochemical Research·Hidechika OzawaShuichi Ueda
Nov 30, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Sophie B SébilleCarine Karachi
Nov 13, 2020·Science Advances·Martin T HenrichD James Surmeier
Mar 3, 2021·Brain Stimulation·Stephano J ChangBrian R Noga
Aug 26, 2021·Cell Reports·Daniel DautanJuan Mena-Segovia
Aug 18, 2018·Neuroscience Research·Charlotte HéricéShuzo Sakata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.