Subpopulations of fetal-like gingival fibroblasts: characterisation and potential significance for wound healing and the progression of periodontal disease

Oral Diseases
Seth L SchorD M Chisholm

Abstract

Wound healing in the adult is commonly compromised by excessive scar formation. In contrast, fetal wound healing is a regenerative process characterised by the conspicuous absence of scarring. Available evidence suggests that phenotypic differences between fetal and adult fibroblasts are important determinants of these distinct modes of tissue repair. In this context, a number of groups (including our own) have documented differences between fetal and adult fibroblasts with respect to such potentially relevant characteristics as migratory activity, motogenic response to cytokines and the synthesis of motility factors, cytokines and matrix macromolecules. The oral mucosa appears to be a privileged site in the adult in that it continues to display a fetal-like mode of wound healing. Data are presented in this review indicating that a subpopulation of gingival fibroblasts expresses several 'fetal-like' phenotypic characteristics. These observations are discussed in terms of both the continued expression of a fetal-like mode of wound healing in the oral mucosa and the possible differential involvement of distinct fibroblast subpopulations in the progression of periodontal disease.

References

Jan 1, 1992·Progress in Growth Factor Research·P MartinJ McCluskey
Aug 1, 1992·Experimental and Molecular Pathology·M PicardoS L Schor
Dec 1, 1992·Journal of Dental Research·L Häkkinen, H Larjava
Feb 1, 1992·The British Journal of Dermatology·H B RasmussenI Leigh
Mar 1, 1990·Matrix : Collagen and Related Research·C N Bertolami, R E Bronson
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A M GreyS L Schor
Aug 1, 1989·The Journal of Cell Biology·C Ffrench-ConstantR O Hynes
Mar 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·G H CockeyT M Hassell
Nov 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R E BronsonC N Bertolami
Jul 1, 1988·Journal of Pediatric Surgery·T M KrummelR F Diegelmann
Jul 1, 1987·Journal of Pediatric Surgery·T M KrummelI K Cohen
Nov 1, 1987·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S L Schor, A M Schor
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K BayreutherP I Francz
Jul 1, 1987·Arthritis and Rheumatism·R L Goldberg, B P Toole
Jan 1, 1970·Acta Orthopaedica Scandinavica·N Rydell
Oct 1, 1971·Journal of Pediatric Surgery·J D Burrington
May 1, 1983·Journal of Periodontal Research·H LimebackJ E Aubin
Jan 1, 1984·Journal of Clinical Periodontology·S S SocranskyJ Lindhe
Jun 10, 1983·Science·R N Feinberg, D C Beebe
Oct 1, 1994·British Journal of Plastic Surgery·U Bertheim, S Hellström
Sep 1, 1995·Journal of Clinical Periodontology·J M MailhotJ B Lewis
Feb 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A PagliariniR Evangelisti

❮ Previous
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Citations

Aug 26, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C R IrwinS L Schor
Mar 22, 2003·Blood·Frank A D T G WagenerCarl G Figdor
Dec 14, 2006·Histopathology·H A HonardoustL Häkkinen
Jul 21, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Bruno GoglyAntoine Lafont
Jun 15, 2012·Journal of Clinical Periodontology·Karim M Fawzy El-SayedChristof E Dörfer
Aug 16, 2013·Stem Cells and Development·Benjamin P J FournierLari Häkkinen
Sep 27, 2014·International Journal of Oral Science·Karim M Fawzy El-SayedChristof Dörfer
Nov 15, 2014·PloS One·Hermann AgisWilliam V Giannobile
Feb 13, 2016·Stem Cells·Keerthi BoddupallyAgnieszka Kobielak
Jul 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kate A LygoeMark P Lewis
Dec 29, 2000·Lasers in Surgery and Medicine·Y J ChenW H Lan
Apr 2, 2003·Journal of Periodontology·Nasser Nooh, Dana T Graves
Jun 25, 2005·Journal of Periodontology·Amir PourzarandianIsao Ishikawa
Sep 23, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Joyce W WongLari Häkkinen
Jan 18, 2013·The Keio Journal of Medicine·Kazuo KishiYoshiaki Kubota
Feb 7, 2014·Molecular Biology of the Cell·Fen GuoAndrew Leask
Oct 12, 2013·British Dental Journal·A A Volponi, P T Sharpe
Mar 20, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Katrien M BrouwerJohannes W Von den Hoff
Apr 24, 2010·Tissue Engineering. Part a·Benjamin P J FournierBruno Gogly
May 26, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Eric DurandAntoine Lafont
Nov 10, 2012·Journal of Clinical Periodontology·Sandra Treves-ManusevitzSandu Pitaru
Apr 14, 2015·Periodontology 2000·Matthias ChiquetDimitris Kletsas
Jan 8, 2017·Journal of Biomedical Materials Research. Part a·Hanlei ZhouChunmao Han
Oct 28, 2019·Journal of Cellular and Molecular Medicine·Quan SunShinji Kuroda
Sep 27, 2005·Journal of Dental Research·H E van BeurdenA M Kuijpers-Jagtman
May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·P StephensD W Thomas
Feb 19, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ameneh EslamiHannu S Larjava
Jan 24, 2007·Oral Diseases·P Stephens, P Genever
Aug 13, 2013·Periodontology 2000·Boris Hinz
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·João Filipe RequichaManuela Estima Gomes
Jul 28, 2020·Life·Marzena Wyganowska-SwiatkowskaTeresa Matthews-Brzozowska
Feb 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hugo E van BeurdenAnne-Marie Kuijpers-Jagtman

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