Subpopulations of M-MDSCs from mice infected by an immunodeficiency-causing retrovirus and their differential suppression of T- vs B-cell responses

Virology
Megan A O'ConnorWilliam R Green

Abstract

Monocytic (CD11b(+)Ly6G(±/Lo)Ly6C(+)) myeloid derived suppressor cells (M-MDSCs) expand following murine retroviral LP-BM5 infection and suppress ex vivo polyclonal T-cell and B-cell responses. M-MDSCs 3 weeks post LP-BM5 infection have decreased suppression of T-cell, but not B-cell, responses and alterations in the degree of iNOS/NO dependence of suppression. M-MDSCs from LP-BM5 infected mice were sorted into four quadrant populations (Ly6C/CD11b density): all quadrants suppressed B-cell responses, but only M-MDSCs expressing the highest levels of Ly6C and CD11b (Q2) significantly suppressed T-cell responses. Further subdivision of this Q2 population revealed the Ly6C(+/Hi) M-MDSC subpopulation as the most suppressive, inhibiting T- and B-cell responses in a full, or partially, iNOS/NO-dependent manner, respectively. In contrast, the lower/moderate levels of suppression by the Ly6C(+/Lo) and Ly6C(+/Mid) M-MDSC Q2 subpopulations, whether versus T- and/or B-cells, displayed little/no iNOS dependency for suppression. These results highlight differential phenotypic and functional immunosuppressive M-MDSC subsets in a retroviral immunodeficiency model.

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Citations

Nov 19, 2015·Developmental and Comparative Immunology·Domenick E KennedyKatherine L Knight
Nov 10, 2015·Developmental and Comparative Immunology·Domenick E KennedyKatherine L Knight
Aug 17, 2016·Journal of Immunology Research·Irina Lyadova VladimirovnaTatiana Nenasheva
Jan 5, 2017·Viral Immunology·Megan A O'ConnorWilliam R Green
Jan 11, 2017·Journal of Zhejiang University. Science. B·Jiu-Kun JiangYuan-Qiang Lu
May 16, 2018·International Journal of Molecular Sciences·Bilgenaz ÖzkanSung-Gyoo Park
Mar 4, 2020·Cells·Andrew M K LawDavid Gallego-Ortega
Jan 23, 2018·Frontiers in Immunology·Anca Dorhoi, Nelita Du Plessis

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