Subpopulations of malignant gliomas in pediatric patients: analysis of the HIT-GBM database.

Journal of Neuro-oncology
Johannes E A WolffChristof M Kramm

Abstract

Pediatric malignant gliomas represent a heterogeneous group of tumors. This publication reviews data from the first three HIT-GBM protocols. One important question is whether it makes sense to include both histologically confirmed high-grade glial tumors (HGG), and radiologically confirmed diffuse intrinsic pontine gliomas in a single study. Three-hundred-and ten patients (173 male, median age 10.0 years) were enrolled. Tumor locations were cerebral hemispheres: 80, basal ganglia: 38, pons: 134, non-pontine brain stem: 14, cerebellum: 14, spinal: 8, and overlapping areas: 22. Surgical resection was complete in 49, subtotal in 35, partial in 58, biopsy in 99, and no surgery in 69 cases. One-hundred-and twenty-three cases corresponded to WHO grade IV, 101 to III, and 15 to I/II. Two-hundred-and twenty-eight patients could be evaluated for response: CR: 8, PR: 32, SD: 116, and PD: 72. Median overall survival time was 1.03 years, and median event free survival was 0.54 years. Five year OS-rate was 10.28 +/- 2.1%. In the total database, tumor location, grading, and extent of surgical resection were prognostic factors, but the relevance differed in location subgroups with no relevance for sex, histological grading or extend of surgic...Continue Reading

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Citations

Apr 7, 2010·Expert Review of Neurotherapeutics·Dattatraya Muzumdar, Enrique C G Ventureyra
Jan 12, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Céline ChappéChristine Edan
Nov 23, 2019·Pediatric Research·Rebecca PötschkeCaspar D Kühnöl
Dec 2, 2008·Journal of Neuro-oncology·Michael KarremannJohannes E A Wolff
May 14, 2011·Journal of Neuro-oncology·Emilie A Steffen-SmithKatherine E Warren
Jun 4, 2011·Neuro-oncology·Christof M KrammJohannes E Wolff
May 30, 2012·Nature Reviews. Clinical Oncology·Chris JonesDarren Hargrave
Jun 12, 2013·Journal of Cancer Research and Clinical Oncology·Christina S MullinsCarl F Classen
Sep 12, 2009·Brain Pathology·Stefaan Van GoolSteven De Vleeschouwer
May 14, 2010·Journal of Pediatric Hematology/oncology·Christopher Alan RokesJohannes E Wolff
Dec 13, 2012·Journal of Neuro-oncology·Zhiping ZhouMark M Souweidane
Oct 27, 2009·Pediatric Blood & Cancer·Sabrina SchlosserMichael C Frühwald
Oct 4, 2011·Journal of Neuro-oncology·Birte WolffJohannes Ea Wolff
Feb 27, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Zhiping ZhouJeffrey P Greenfield
Jul 27, 2010·Pediatric Blood & Cancer·Johannes E A WolffAstrid Gnekow
Aug 23, 2011·Journal of Neuro-oncology·Johannes E WolffAnita Mahajan
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Aug 10, 2010·Journal of Neuro-oncology·Johannes E WolffChristoph Kramm
Jan 19, 2013·Paediatric Drugs·Trent R HummelDavid Franz

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