Subpopulations of neonatal rat sensory neurons express functional neurotransmitter receptors which elevate intracellular calcium

Neuroscience
D BowieRémy Schlichter

Abstract

We have attempted to identify which subpopulations of rat sensory neurons possess functional neurotransmitter receptors which elevate the free concentration of intracellular calcium. Subpopulations of sensory neurons were identified using three accepted criteria: (i) the distribution and proportion of neurons with differing somatic diameters; (ii) the expression of substance P-like immunoreactivity; and (iii) the responsiveness of each neuron to capsaicin. The total neuronal population was primarily grouped into three classes according to somatic diameter and defined as small- (< 17 microns), intermediate- (17-25 microns) and large- (> 25 microns) sized neurons. It was not possible to distinguish between small and intermediate-sized neurons since a similar percentage of each class expressed substance P-like immunoreactivity or sensitivity to capsaicin. Large-sized neurons did not possess these characteristics and, therefore, represented a distinct neuronal population. In single, intact neurons of differing diameter, the ability of a variety of receptor agonists to elevate the free concentration of intracellular calcium was determined using the calcium-sensitive indicator, Fura-2. Local application of capsaicin, adenosine, brady...Continue Reading

References

Aug 20, 1976·Brain Research·P J Roberts
Jan 1, 1991·Progress in Neurobiology·R J Miller
Sep 22, 1990·Proceedings. Biological Sciences·J N WoodM Theveniau
Aug 1, 1990·Trends in Pharmacological Sciences·S Bevan, J Szolcsányi
Jul 1, 1988·British Journal of Pharmacology·R H ScottA C Dolphin
Jan 1, 1987·Experimental Brain Research·A M Horn, S L Lightman
Dec 2, 1986·European Journal of Pharmacology·D Weinreich
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P I Baccaglini, P G Hogan
Feb 1, 1984·British Journal of Pharmacology·M DésarmenienR Schlichter
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·J DoddT M Jessell
Feb 1, 1983·Journal of Neurocytology·A RambourgA Beaudet
Feb 21, 1980·Nature·J P GallagherP Shinnick-Gallagher
Jan 1, 1991·The European Journal of Neuroscience·M. M. BouvierC. D. Benham

❮ Previous
Next ❯

Citations

Jun 10, 2006·Cellular and Molecular Neurobiology·Patrícia Aline Boer, José Antonio Rocha Gontijo
Jan 1, 1996·Brain Research. Molecular Brain Research·T AndohY Kuraishi
Feb 1, 1997·Journal of Neuroscience Methods·R Gilabert, P McNaughton
Feb 6, 1999·Journal of the Autonomic Nervous System·H E RaybouldE A Mayer
Mar 21, 1998·Neuroscience Letters·C BrechenmacherJ L Rodeau
Jul 23, 2002·Autonomic Neuroscience : Basic & Clinical·Eleanor ChungLu-Yuan Lee
May 9, 2000·Biochemical and Biophysical Research Communications·S J KimJ Kim
Apr 1, 1998·Journal of Neuroimmunology·L M BolinK B Bacon
Jun 29, 2007·The European Journal of Neuroscience·Lauriane UlmannRémy Schlichter
Mar 29, 2012·British Journal of Pharmacology·S HugelR Schlichter
Mar 17, 2004·British Journal of Pharmacology·Rhian M EvansRuth A Ross
May 19, 1997·The Journal of Comparative Neurology·V S SeyboldB R Southwell
Jan 19, 2018·Scientific Reports·Sarah LalisseLauriane Ulmann
Jan 12, 2012·Bulletin of Experimental Biology and Medicine·M A NakvasinaV G Artyukhov
Feb 17, 1998·Journal of Medicinal Chemistry·Y RivalC G Wermuth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.