Subpopulations of neurons expressing parvalbumin in the human amygdala.

The Journal of Comparative Neurology
Harry PantazopoulosSabina Berretta

Abstract

Amygdalar intrinsic inhibitory networks comprise several subpopulations of gamma-aminobutyric acidergic neurons, each characterized by distinct morphological features and clusters of functionally relevant neurochemical markers. In rodents, the calcium-binding proteins parvalbumin (PVB) and calbindin D28k (CB) are coexpressed in large subpopulations of amygdalar interneurons. PVB-immunoreactive (-IR) neurons have also been shown to be ensheathed by perineuronal nets (PNN), extracellular matrix envelopes believed to affect ionic homeostasis and synaptic plasticity. We tested the hypothesis that differential expression of these three markers may define distinct neuronal subpopulations within the human amygdala. Toward this end, triple-fluorescent labeling using antisera raised against PVB and CB as well as biotinylated Wisteria floribunda lectin for detection of PNN was combined with confocal microscopy. Among the 1,779 PVB-IR neurons counted, 18% also expressed CB, 31% were ensheathed in PNN, and 7% expressed both CB and PNN. Forty-four percent of PVB-IR neurons did not colocalize with either CB or PNN. The distribution of each of these neuronal subgroups showed substantial rostrocaudal gradients. Furthermore, distinct morphologi...Continue Reading

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Citations

Sep 9, 2011·Journal of Neurophysiology·Fu-Sun LoReha S Erzurumlu
Feb 4, 2016·Neural Plasticity·Harry Pantazopoulos, Sabina Berretta
Jan 25, 2011·The European Journal of Neuroscience·Fiona E RandallMark O Cunningham
Aug 23, 2011·Neuropharmacology·Sabina Berretta
Jun 4, 2016·Neuroscience·Basilis ZikopoulosHelen Barbas
Mar 6, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Gabriele CheliniSabina Berretta
Nov 24, 2016·Frontiers in Aging Neuroscience·Dustin H BrewtonKhaleel A Razak
Apr 13, 2021·Frontiers in Behavioral Neuroscience·Eden M AndersonMatthew Hearing

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