PMID: 9541823May 9, 1998Paper

Subretinal administration of tissue-type plasminogen activator to speed the drainage of subretinal hemorrhage

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
S SaikaY Ohnishi

Abstract

Bleeding into the subretinal space in the vicinity of the macula is associated with age-related macular degeneration or retinal arterial macroaneurysm. The prognosis for restoration of vision is poor in the presence of blood clots. Using a simple device composed of three disposable syringes we injected tissue-type plasminogen activator (tPA) into the subretinal space during conventional vitrectomy in six patients to assist the draining of subretinal clots. Four of six patients recovered their visual acuity postoperatively, while visual acuity in the other patients was stabilized. Early drainage of subretinal hemorrhage assisted by the introduction of tPA into the subretinal space led to uncomplicated surgery and favorable postoperative results.

Citations

Mar 21, 2006·The British Journal of Ophthalmology·R P SinghJ E Sears
Jun 3, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Sumit P ShahSteven D Schwartz
Nov 25, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Makoto InoueAkito Hirakata
Apr 5, 2000·Seminars in Ophthalmology·M KameiH Lewis
Jul 9, 2020·International Journal of Retina and Vitreous·Carsten GrohmannChristos Skevas

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