PMID: 9121756Jul 1, 1995Paper

Subretinal fibrosis in central serous chorioretinopathy

Ophthalmology
H SchatzD M Robertson

Abstract

To report unusual and heretofore unreported visually damaging manifestations of severe central serous chorioretinopathy. Case studies. Each of six male patients (average age, 40 years) had a form of severe central serous chorioretinopathy with at least one eye containing fibrin in the subretinal space that then developed into a subretinal fibrotic scar. Scar formation was followed by a tenting up of the macula, vascularization of the fibrosis (subretinal neovascularization), or a retinal pigment epithelial rip. Four of the seven eyes with subretinal fibrosis had severe visual loss (20/400 or worse). Subretinal fibrin and other extracellular matrix molecules appear to stimulate the retinal pigment epithelium to undergo fibrous metaplasia, which results in subretinal fibrotic scar formation and other sequelae, all of which can lead to severe visual loss.

References

Nov 1, 1979·American Journal of Ophthalmology·R C WatzkeR F Woolson
May 16, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·I Tsukahara, M Uyama
Feb 1, 1990·Ophthalmology·G A JaffeD P Han
Jan 1, 1990·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T R Friberg, A W Eller
Aug 15, 1989·American Journal of Ophthalmology·G A JaffeG W Abrams
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T R Friberg, J Campagna
Aug 1, 1988·Archives of Ophthalmology·G A WilliamsG W Abrams
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·B Daicker
Jun 1, 1970·The British Journal of Ophthalmology·J Williamson, G Nuki
Apr 1, 1974·Archives of Ophthalmology·M L KleinS Chandra
Jul 1, 1974·American Journal of Ophthalmology·R H Bedrossian
Jul 1, 1972·Archives of Ophthalmology·D M AlbertA S Rabson
Dec 1, 1984·Ophthalmology·A E JalkhC L Schepens
Sep 1, 1984·Archives of Ophthalmology·J S Vidaurri-Leal, B M Glaser
Nov 1, 1984·The British Journal of Ophthalmology·C M GilbertS L Fine
Jul 1, 1983·Archives of Ophthalmology·D M Fastenberg, R R Ober
May 1, 1984·The British Journal of Ophthalmology·M Wakakura, S Ishikawa
Jan 1, 1981·The Kurume Medical Journal·H YoshiokaR Ishibashi
Nov 1, 1993·The British Journal of Ophthalmology·H SchatzRobert N Johnson
Sep 1, 1993·Archives of Ophthalmology·Evrydiki A BouzasM I Kaiser-Kupfer

Citations

Nov 15, 2002·Survey of Ophthalmology·Evrydiki A BouzasConstantin J Pournaras
Aug 31, 2000·Ophthalmology·I C KuoE T Cunningham
Apr 5, 2005·Retina·H Richard McDonaldJoseph A Khawly
Aug 14, 2008·Retina·Felice Cardillo PiccolinoSimonetta Cicinelli
Sep 10, 2008·Retina·Felice Cardillo PiccolinoGiambattista Ravera
Dec 16, 2010·Retina·Mariko HirayamaPearse A Keane
Apr 27, 2000·The British Journal of Ophthalmology·D K SahuN F de Sousa
Dec 1, 1996·Ophthalmology·E T CunninghamA R Irvine
May 7, 2009·Acta Ophthalmologica·Julie GueudryGérard Brasseur
Nov 3, 2009·Clinical & Experimental Ophthalmology·Bhaskar GuptaSobha Sivaprasad
Dec 27, 2005·American Journal of Ophthalmology·Masahiro MiuraTakuya Iwasaki
Jul 31, 2007·Acta Ophthalmologica·Maria WangMichael Larsen
Apr 17, 2016·Ophthalmology·Chandrakumar BalaratnasingamLawrence A Yannuzzi
Mar 14, 2012·Ocular Immunology and Inflammation·Moncef KhairallahIlknur Tugal-Tutkun
Aug 9, 2006·Korean Journal of Ophthalmology : KJO·Ji Eun KangJeong Hee Lee
Aug 7, 2009·Ocular Immunology and Inflammation·Paradee KunavisarutAniki Rothova
Apr 6, 2018·International Journal of Retina and Vitreous·Vikas AmbiyaJay Chhablani
May 17, 2006·European Journal of Ophthalmology·K Hotta
Dec 21, 2019·Indian Journal of Ophthalmology·Niroj K SahooJay Chhablani
Jul 19, 2019·Progress in Retinal and Eye Research·Thomas J van RijssenCamiel J F Boon
May 15, 2020·Progress in Retinal and Eye Research·Rebecca KayeAndrew Lotery

Related Concepts

Body Fluids
Exudates and Transudates
Antithrombin I
Cirrhosis
Fluorescence Photography, Fundus
Structure of Fundus of Eye
Retina
Retinal Pigment Epithelial Detachment
Retinal Diseases
Visual Impairment

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.