Subsecond multisection CT of regional pulmonary ventilation

Academic Radiology
J K TajikEric A Hoffman

Abstract

To evaluate the adequacy of multibreath and single-breath stable xenon gas techniques to measure regional ventilation during cardiac-gated, high-speed, multisection imaging, the authors carried out a series of studies using electron-beam computed tomography (CT) and a recently introduced subsecond multisection spiral CT scanner. In four anesthetized pigs, the authors implemented single-breath and/or dynamic multibreath wash-in and washout protocols with respiratory-- and cardiac-gated image acquisition. The effects of varying tidal volume and inspiratory flow rate were evaluated independently. Scanning was done at end expiration to avoid artifacts from partial volumed conducting airways, which are filled with inspired gas concentration during inspiration. A single breath of 100% xenon provides adequate enhancement in the lung parenchyma (mean, 32 HU +/- 1.85 [standard error]) and should not cause unwanted side effects (mean xenon concentration in lung periphery, 21%). The single-breath method is suitable for studies requiring only short periods of apnea. Using the multibreath method, in dependent portions of the lung, there was close agreement between measured changes and predictions based on the xenon calibration data. More th...Continue Reading

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Citations

Nov 18, 2005·Pediatric Radiology·Michael Puderbach, Hans-Ulrich Kauczor
Jul 24, 2008·Pediatric Radiology·Michael Puderbach, Hans-Ulrich Kauczor
Dec 8, 2006·European Radiology·Thorsten R C JohnsonChristoph R Becker
Jun 24, 2010·European Radiology·Sven F ThiemeThorsten R C Johnson
Nov 1, 2003·Academic Radiology·Warren B Gefter, Hiroto Hatabu
Dec 15, 2005·Proceedings of the American Thoracic Society·Eric A Hoffman, Deokiee Chon
May 31, 2013·Medical Physics·Kaifang DuJoseph M Reinhardt
Mar 3, 2012·Medical Physics·Kaifang DuJoseph M Reinhardt
Oct 1, 2010·Medical Physics·Shigeru SaseMitsuru Honda
Jul 10, 2012·Respiratory Physiology & Neurobiology·Jennine H MitchellMerryn H Tawhai
Jun 4, 2011·The Journal of Allergy and Clinical Immunology·Mario CastroUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Nov 27, 2010·European Journal of Radiology·Long-Jiang ZhangGuang-Ming Lu
Dec 10, 2009·Radiologic Clinics of North America·Martine Remy-JardinJacques Remy
Feb 13, 2008·Clinics in Chest Medicine·Edwin J R van Beek, Eric A Hoffman
Dec 15, 2004·Academic Radiology·Eric A HoffmanGe Wang
Jul 18, 2006·Academic Radiology·Eric A Hoffman, Edwin van Beek
Jun 17, 2006·Academic Radiology·R Blaine EasleyBrett A Simon
Jan 10, 2006·Academic Radiology·John Arbash MeinelGe Wang
Oct 29, 2005·Academic Radiology·Solbert Permutt
Oct 29, 2005·Academic Radiology·Osama I SabaEric A Hoffman
Oct 29, 2005·Academic Radiology·Brett A Simon
Oct 29, 2005·Academic Radiology·Martin C FischerRahim R Rizi
Aug 3, 2005·Respiratory Physiology & Neurobiology·Deokiee ChonEric A Hoffman
Dec 22, 2007·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·William E HigginsKun-Chang Yu
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertJohn P Mugler
Jul 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rahim R RiziWarren Gefter
Aug 24, 2004·Journal of Applied Physiology·Merryn H TawhaiEric A Hoffman
Feb 10, 2006·Physics in Medicine and Biology·Thomas GuerreroRitsuko Komaki

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