Subsequent Bilateral Hippocampal Diffusion Restriction and Atrophy in Repeated Status Epilepticus

The Neurodiagnostic Journal
Timo SiepmannUlf Bodechtel

Abstract

Cortical lesions in status epilepticus have been reported but the underlying mechanisms are poorly elucidated. We report on afemale patient (75 years) with a history of alcohol abuse who presented with complex partial status epilepticus and lateralized epileptiform discharges in the left frontal and temporal regions in EEG. While cranial magnetic resonance imaging (MRI) showed left hippocampal T2-hyperintensity and diffusion restriction, cerebrospinal fluid was normal and revealed no limbic encephalitis-related antibodies. Following treatment with levitiracetam, seizures ceased and the patient was dismissed. Nine months later, she was readmitted with generalized status epilepticus. Cranial MI now showed hippocampal diffusion restriction and T2 hyperintensity, but in the right hemisphere, as well as atrophy and partial gliotic transformation of the initially affected left hippocampus. Although hippocampal damage due to antibody-negative limbic encephalitis cannot be ruled out, our observation of subsequent bilateral hippocampal diffusion restriction with gliotic transformation may demonstrate permanent seizure-induced structural brain damage and underlines the importance of further research to elucidate the effects of prolonged ...Continue Reading

References

Jan 1, 1993·Epilepsia·C G WasterlainR Sankar
Apr 2, 1999·Neurology·M G LansbergG W Albers
Nov 24, 2005·Epilepsia·Simon Shorvon, Matthew Walker
Apr 6, 2006·Neuroradiology·Horst UrbachChristian G Bien
Apr 15, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·A O RossettiE B Bromfield
Jul 2, 2008·Nature Reviews. Drug Discovery·Geoffrey Burnstock
Jun 17, 2011·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Souhel NajjarOrrin Devinsky
Aug 17, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hea Kyung ChoiTae-Cheon Kang
Dec 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tobias EngelMiguel Diaz-Hernandez
Jan 20, 2012·Epileptic Disorders : International Epilepsy Journal with Videotape·Fehim ArmanM Necmettin Pamir
May 28, 2013·Seizure : the Journal of the British Epilepsy Association·Katharina PernhorstAlexander Grote
Mar 13, 2014·Epilepsy & Behavior : E&B·A M CartagenaS M Mirsattari
Apr 23, 2014·CNS Neuroscience & Therapeutics·Guillaume MesuretDavid C Henshall
Aug 8, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ukpong B EyoLong-Jun Wu
Apr 7, 2015·Epilepsy & Behavior : E&B·David C Henshall, Tobias Engel
Apr 25, 2015·Lancet Neurology·John P Betjemann, Daniel H Lowenstein

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.