Subsequent risk of metabolic syndrome in women with a history of preeclampsia: data from the Health Examinees Study

Journal of Epidemiology
Jae Jeong YangDaehee Kang

Abstract

To investigate whether preeclampsia is independently associated with risk of future metabolic syndrome and whether any such primary associations are modified by different ages at first pregnancy. Based on the Health Examinees Study, a cross-sectional analysis was conducted. Data of women (n = 49 780) who had experienced at least 1 pregnancy during their lifetime and had never been diagnosed with any metabolic disorder before their pregnancy were analyzed using multiple logistic regression models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated after adjusting for age, lifestyle characteristics, and reproductive factors. A stratified analysis was also conducted to estimate the extent of the primary association between preeclampsia and future metabolic syndrome by age at first pregnancy. Women with a history of preeclampsia had significantly increased odds of developing metabolic syndrome (adjusted OR 1.23; 95% CI, 1.12-1.35), central obesity (adjusted OR 1.36; 95% CI, 1.25-1.47), elevated blood pressure (adjusted OR 1.53; 95% CI, 1.41-1.67), or elevated fasting glucose (adjusted OR 1.13; 95% CI, 1.03-1.25) in later life. In the stratified analysis, women who first became pregnant at ages >35 years and had pre...Continue Reading

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Citations

Feb 26, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Shi-Sheng ZhouNa-Na Chen
Jan 28, 2014·The Journal of Infection·Elizabeth Stankiewicz MachadoUNKNOWN NICHD International Site Development Initiative (NISDI) Pediatric Protocol
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