Subsequent surgery rates after cervical total disc replacement using a Mobi-C Cervical Disc Prosthesis versus anterior cervical discectomy and fusion: a prospective randomized clinical trial with 5-year follow-up

Journal of Neurosurgery. Spine
Robert J JacksonPierce D Nunley

Abstract

OBJECTIVE Cervical total disc replacement (TDR) has been shown in a number of prospective clinical studies to be a viable treatment alternative to anterior cervical discectomy and fusion (ACDF) for the treatment of symptomatic degenerative disc disease. In addition to preserving motion, evidence suggests that cervical TDR may result in a lower incidence of subsequent surgical intervention than treatment with fusion. The goal of this study was to evaluate subsequent surgery rates up to 5 years in patients treated with TDR or ACDF at 1 or 2 contiguous levels between C-3 and C-7. METHODS This was a prospective, multicenter, randomized, unblinded clinical trial. Patients with symptomatic degenerative disc disease were enrolled to receive 1- or 2-level treatment with either TDR as the investigational device or ACDF as the control treatment. There were 260 patients in the 1-level study (179 TDR and 81 ACDF patients) and 339 patients in the 2-level study (234 TDR and 105 ACDF patients). RESULTS At 5 years, the occurrence of subsequent surgical intervention was significantly higher among ACDF patients for 1-level (TDR, 4.5% [8/179]; ACDF, 17.3% [14/81]; p = 0.0012) and 2-level (TDR, 7.3% [17/234]; ACDF, 21.0% [22/105], p = 0.0007) trea...Continue Reading

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Citations

Jan 13, 2018·Neurosurgery·Pierce D NunleyMarcus B Stone
Jan 10, 2019·International Orthopaedics·Andrei F JoaquimK Daniel Riew
Mar 26, 2019·Expert Review of Medical Devices·Siddharth A BadveWilliam F Lavelle
May 11, 2019·Journal of Neurosurgery. Spine·Tsung-Hsi TuHenrich Cheng
Jul 19, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Martin SkeppholmTycho Tullberg
Oct 5, 2018·The Journal of the American Academy of Orthopaedic Surgeons·Theodore D KoreckijDaniel K Park
Mar 25, 2017·Current Reviews in Musculoskeletal Medicine·Kristen RadcliffSheeraz Qureshi
Apr 18, 2018·Global Spine Journal·Jordan C XuThomas E Mroz
Apr 2, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Michael P KellyNelson F SooHoo
Feb 6, 2018·Experimental and Therapeutic Medicine·Hongtao WeiYongpeng Meng
Jan 31, 2018·Expert Review of Medical Devices·Siddharth A BadveWilliam F Lavelle
Apr 12, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jack E ZiglerDonna D Ohnmeiss
Sep 24, 2020·The Spine Journal : Official Journal of the North American Spine Society·Sohrab VirkSheeraz Qureshi
Sep 20, 2017·The Journal of Bone and Joint Surgery. American Volume·Alfredo ArrojasGregory Grabowski
Apr 6, 2021·Neurospine·Andrei Fernandes JoaquimK Daniel Riew
May 4, 2021·The Spine Journal : Official Journal of the North American Spine Society·Daniel CobanArash Emami

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NCT00389597

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