Subsequent thoracic cancers among patients diagnosed with lung cancer: a SEER database analysis

Current Medical Research and Opinion
Omar Abdel-Rahman, Winson Y Cheung

Abstract

Population-based data on the development of subsequent thoracic cancers following the initial diagnosis of lung cancer are scarce. We evaluated this clinical scenario in lung cancer patients registered within the Surveillance, Epidemiology and End Results (SEER) database. The SEER database (1988-2013) was queried using the SEER*Stat program to determine the clinico-pathological features of lung cancer patients who develop subsequent thoracic cancers as well as the characteristics of these subsequent cancers. Associations were ascertained with chi-squared tests and survival analysis was performed using Kaplan-Meier methods. Standardized incidence ratios (SIRs) were calculated to determine the risk of each type of subsequent cancer. A total of 223,274 lung cancer patients were identified and included in the current study. In this cohort, 6387 patients developed subsequent thoracic cancers. The following were associated with a higher likelihood of second cancers: female gender, younger age, white race, adenocarcinoma histology, married, lower AJCC stage, earlier year of diagnosis and local treatment with surgery rather than radiotherapy (p < .0001 for all parameters). In the subset of patients with subsequent thoracic cancers, sur...Continue Reading

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May 24, 2017·Current Medical Research and Opinion·Omar Abdel-Rahman, Winson Y Cheung

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Citations

May 24, 2017·Current Medical Research and Opinion·Omar Abdel-Rahman, Winson Y Cheung
Jul 1, 2021·Radiation and Environmental Biophysics·Xinyu SongYeqing Guo
Dec 14, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marian EberlStefanie J Klug

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