Subsets of thymopoietic rat thymocytes defined by expression of the CD2 antigen and the MRC OX-22 determinant of the leukocyte-common antigen CD45.

European Journal of Immunology
D A LawA F Williams

Abstract

The MRC OX-22 monoclonal antibody recognizes a restricted determinant of the rat leukocyte-common antigen (L-CA, CD45), which is expressed on most peripheral T cells and all B cells. In contrast only 2%-3% of thymocytes are OX-22+ and these are now shown to be mostly of the immature CD4-CD8- (double-negative, DN), phenotype with very few of the mature phenotype cells being OX-22+. Analysis of immunoperoxidase sections suggests that the DN OX-22+ cells are located in the cortex. Among the DN cells about 60% are OX-22+ and a similar percentage are positive for CD2 antigen. Double staining showed that OX-22+CD2-, OX-22+CD2+, and OX-22-CD2+ populations can be defined and that these three sets account for approximately 95% of the DN cells. Measurement of the thymopoietic activity of DN subsets showed that OX-22+CD2- and OX-22+CD2+ cells have regenerative capacity whilst OX-22-CD2+ cells do not.

References

Jan 1, 1989·Annual Review of Immunology·M L Thomas
Nov 1, 1989·Pathology, Research and Practice·P FelmanP A Bryon
Jan 1, 1987·The Journal of Experimental Medicine·D J PatersonA F Williams
Feb 1, 1987·The Journal of Experimental Medicine·A F WilliamsA C Willis
Jul 1, 1985·The Journal of Experimental Medicine·W A JefferiesA F Williams
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Feb 1, 1974·European Journal of Immunology·J C Jensenius, A F Williams

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Citations

Jan 1, 1991·Research in Immunology·F PowrieD Mason
Nov 21, 1998·Immunology·J SinkoraB De Geus
Dec 1, 1992·The Journal of Experimental Medicine·V A WallaceT W Mak
Nov 8, 1990·Nature·E B Bell, S M Sparshott
Aug 7, 2013·Experimental Biology and Medicine·Nevena Arsenović-RaninGordana Leposavić
May 24, 2019·Biogerontology·Mirjana Nacka-AleksićGordana Leposavić
Sep 1, 1990·European Journal of Immunology·M A DeugnierJ P Thiery
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L M Alonso-CA G Zapata
Jan 1, 1994·European Journal of Immunology·D A WitherdenR N Cahill

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