PMID: 9550189Apr 29, 1998Paper

Subspecies of protein kinase C in the rat spinal cord

Progress in Neurobiology
M Akinori

Abstract

In this review, the developmental expression of alpha-, beta- and gamma-subspecies of protein kinase C (PKC) in the rat spinal cord was summarized, and possible roles of this protein for neuronal differentiation were discussed. Faint immunoreactivity (IR) for PKCs was first demonstrated in the cervical spinal cord on embryonic day 13 (E-13). It gradually became stronger, and between E-18 and postnatal day 0 (P-0), strong IR for these three subspecies was uniformly distributed throughout the spinal cord. While thereafter, it irregularly declined, and reached the adult pattern around P-28 or P-35. The motor neurons began to express these three subspecies of PKC in the nucleus, perikaryal cytoplasm, dendrites and axons, soon after they began to differentiate. In the perikaryal cytoplasm, the IR was expressed mainly on ribosomes, and in the dendrites, mainly on cytoskeletal elements. At the late embryonic and early postnatal stages, IR for these PKCs was expressed both in the presynaptic terminals and on the postsynaptic densities. While thereafter, the IR in the former declined, and was detected only on the postsynaptic densities. The dorsal corticospinal tract transiently expressed strong IR for these PKCs at the early postnatal ...Continue Reading

References

May 1, 1975·The American Journal of Anatomy·S P Hicks, C J D'Amato
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·N H SternbergerH D Webster
Sep 15, 1977·The Journal of Comparative Neurology·J M Donatelle
Oct 1, 1976·The Journal of Comparative Neurology·R P SkoffA Stocks
May 1, 1975·Developmental Biology·P C Letourneau
Oct 1, 1992·Molecular Biology of the Cell·D N DrechselM W Kirschner
Jul 1, 1992·Journal of Neuroscience Research·N R BhatM S Kindy
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J B WatsonR S Fisher
Jan 1, 1991·Neuroscience·M FitzgeraldL I Benowitz
Jul 1, 1991·Journal of Neuroscience Research·S KomolyK F Chan
Dec 15, 1990·Brain Research. Developmental Brain Research·W G JiaM S Cynader
Mar 30, 1990·Biochemical and Biophysical Research Communications·Y GondaM Inagaki
Sep 28, 1990·Biochemical and Biophysical Research Communications·F S SheuA Routtenberg
Oct 1, 1990·Brain Research. Molecular Brain Research·W G JiaM S Cynader
Apr 1, 1990·Brain Research. Developmental Brain Research·M A Cambray-DeakinR D Burgoyne
Aug 1, 1990·Journal of Neuroscience Research·J B WatsonJ G Sutcliffe
Oct 1, 1990·Journal of Neuroscience Research·M J Noetzel
Jan 1, 1990·The Journal of Comparative Neurology·P E PhelpsJ E Vaughn
Mar 1, 1990·Brain Research. Developmental Brain Research·F L HuangK P Huang
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M ArquintR Dunn
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C LaiJ G Sutcliffe

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Citations

Mar 17, 2004·Brain Research·Jannon L FuchsHarris D Schwark
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masanori SasakiJeffery D Kocsis
Dec 26, 2007·Experimental Neurology·Guillermo García-AlíasJames W Fawcett
Sep 5, 2007·The European Journal of Neuroscience·Angela Maria VergnanoPierrick Poisbeau
Sep 1, 2004·The Journal of Pain : Official Journal of the American Pain Society·Daphné A Robinson, Min Zhuo
Sep 27, 2006·Trends in Pharmacological Sciences·Chris P BaileyGraeme Henderson
Aug 9, 2005·The Journal of Pain : Official Journal of the American Pain Society·Jennifer A ShumillaSarah M Sweitzer
May 28, 2011·The Journal of Comparative Neurology·Jessica L NielsonOswald Steward
Jun 28, 2016·Developmental Neurobiology·Noemie Mermet-JoretMyriam Antri
Mar 12, 2011·Journal of Dental Research·A NakajimaK Iwata
Aug 18, 2005·Genesis : the Journal of Genetics and Development·Yu-Qiang DingZhou-Feng Chen
Feb 6, 2004·The Journal of Pharmacology and Experimental Therapeutics·Sarah M SweitzerJoan J Kendig
Oct 25, 2007·Biochemical Society Transactions·J E R WilkersonG S Mitchell
Oct 2, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Francisco Javier Rodriguez-JimenezSlaven Erceg
Nov 24, 2021·Experimental Neurology·Olaia Baylo-MarínGuillermo García-Alías

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