Substance P analogues containing D-histidine antagonize the behavioural effects of intrathecally co-administered substance P in mice.

European Journal of Pharmacology
T SakuradaM Ohba

Abstract

The antagonistic effect of newly synthesized substance P (SP) analogues containing D-histidine was examined on behavioural responses induced in mice by SP, neurokinin (NK) A, physalaemin, eledoisin, somatostatin and bombesin. [D-Pro2,D-Trp7,9]SP (DPDT-SP) and [D-Arg1,D-Trp7,9,Leu11]SP (spantide) were used as references for comparison. When co-administered with SP intrathecally, all the SP analogues used decreased the SP-induced response which consists of scratching, biting and licking. DPDT-SP and spantide attenuated non-specifically the SP-like behavioural responses induced by physalaemin, eledoisin, NK A and somatostatin. In general, the introduction of D-histidine in position 9 of the SP molecule resulted in potent antagonistic activity of the SP derivative on the behavioural responses to SP. Of these SP analogues, [D-Arg1,D-Pro2,4,D-Phe7,D-His9]SP attenuated selectively the behavioural responses produced by NK-1 receptor agonists such as SP and physalaemin. Simultaneous injection of [D-Phe7,D-His9]SP-(6-11) selectively inhibited the SP-induced behavioural response without affecting the other peptide-induced behavioral response. The results suggest that the behavioural antagonism induced by [D-Arg1,D-Pro2,4,D-Phe7,D-His9]SP ...Continue Reading

References

Jul 31, 1985·European Journal of Pharmacology·C Post, K Folkers
Sep 24, 1985·European Journal of Pharmacology·P Le GrevesT Hökfelt
Aug 1, 1985·Neuropharmacology·H MatsumuraK Kisara
Apr 1, 1987·Neuropeptides·T SakuradaE Munekata
Nov 1, 1987·Pain·D Papir-KricheliM Devor
Dec 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·H KuwaharaE Munekata
Feb 23, 1988·Brain Research·T SakuradaL Terenius
Dec 19, 1988·Neuroscience Letters·T SakuradaL Terenius
Mar 1, 1985·Journal of Neurochemistry·T SakuradaL Terenius
Dec 31, 1981·Biochemical and Biophysical Research Communications·F LembeckJ Donnerer
Aug 17, 1984·European Journal of Pharmacology·J L VaughtD Wright
Nov 30, 1984·Biochemical and Biophysical Research Communications·F NybergL Terenius
Oct 17, 1980·European Journal of Pharmacology·J L Hylden, G L Wilcox

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Citations

Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·T SakuradaK Kisara
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·T SakuradaK Kisara
Jul 2, 1993·Regulatory Peptides·T SakuradaL Terenius
Jan 12, 1993·Neuroscience Letters·J KameiY Kasuya
Jun 7, 2005·Neurotoxicology·Tsukasa SakuradaShinobu Sakurada
May 4, 1999·European Journal of Pharmacology·T SakuradaS Sakurada
Jul 28, 1999·Peptides·C SakuradaT Sakurada
Aug 24, 1999·British Journal of Pharmacology·T SakuradaJ Sasaki
May 16, 2009·Peptides·Eleni KatsouniCharis Liapi
Oct 16, 1992·Brain Research·T SakuradaL Terenius

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