Substance P and bradykinin hyperpolarize pig coronary artery endothelial cells in primary culture.

Blood Vessels
P C Brunet, J L Bény

Abstract

Substance P (SP) and bradykinin (BK) relax and hyperpolarize smooth muscles of pig coronary arteries in an endothelium-dependent manner. We investigated the effect of both peptides on the membrane potential of endothelial cells in culture. The membrane potential of pig coronary artery endothelial cells in primary culture was -44 mV. SP and BK hyperpolarized it transiently by 23 mV. These hyperpolarizations were dependent on the potassium gradient across the cellular membrane. They had similar time courses as the SP and BK endothelium-dependent hyperpolarizations already observed in smooth muscles.

Citations

Jan 1, 1989·Tissue & Cell·J L Bény, F Gribi
Mar 19, 1999·European Journal of Pharmacology·Y TanakaK Shigenobu
Nov 20, 1997·The Journal of Physiology·P Y von der Weid, D F Van Helden
May 20, 2004·Journal of Cardiovascular Electrophysiology·David J Adams, Michael A Hill
Dec 1, 1992·Journal of Autonomic Pharmacology·P Sneddon, A Graham

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