PMID: 9523575Apr 2, 1998Paper

Substance P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6

Journal of Neurochemistry
K LiebB L Fiebich

Abstract

Interleukin-6 (IL-6) is a proinflammatory cytokine whose synthesis is induced by a variety of stimuli including interleukin-1 (IL-1), substance P (SP), and histamine. Because IL-6 has been implicated in the etiopathology of different human diseases including multiple myeloma, rheumatoid arthritis, multiple sclerosis, acquired immunodeficiency syndrome dementia complex, and Alzheimer's disease, its inhibition may be of therapeutic interest. A main demand on an effective inhibitor of IL-6 expression is that it inhibits IL-6 synthesis independently of the inducing stimulus. We therefore used human astrocytoma cells to search for signal transduction cascades and transcription factors whose inhibition suppresses IL-6 synthesis after stimulation with three different inductors, IL-1beta, SP, and histamine. Whereas the antioxidant pyrrolidinedithiocarbamate was only able to inhibit IL-1beta-induced IL-6 expression, inhibition of protein kinase C prevented IL-6 expression induced by all three substances. Promoter deletion analysis revealed that IL-1beta-induced IL-6 expression required the transcription factor nuclear factor-kappaB (NF-kappaB), whereas SP- and histamine-induced IL-6 synthesis was essentially controlled by NF-IL-6. These...Continue Reading

Citations

Feb 17, 2017·International Journal of Molecular Medicine·Keisuke YamaguchiIsao Nagaoka
Oct 31, 2007·Infection and Immunity·Birte PantenburgA Clinton White
May 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Helmut FriessMarkus W Büchler
Apr 15, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Inga Herpfer, Klaus Lieb
Oct 12, 2016·Journal of Neuroinflammation·Frances CorriganRobert Vink
Mar 14, 2000·Experimental Eye Research·L N FleisherJ B Ferrell
Mar 1, 2000·Journal of Neuroimmunology·N J Van Wagoner, E N Benveniste

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Transcription

Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.