PMID: 6167970Jan 1, 1981Paper

Substance P and leucine-enkephalin changes after chordotomy and morphine treatment

Peptides
N E NaftchiL L Vacca

Abstract

Spinal cords of rats, cats and monkeys were transected; the animals were perfused at varying times. Other rats were injected with morphine and perfused 10 days later. Immunocytochemistry shows substance P (SP) present in control animals primarily in the substantia gelatinosa (SG) of the dorsal horn of the spinal cord. Slight SP immunoreactivity is found in the ventral horn and near the central canal. Starting a few days after transection, there is a buildup of reaction product in the dorsal horn, in sections cut from below the lesion; staining above remains the same. With time, after chordotomy, SP immunoreactivity appears in fibers in lamina V, only in sections below the lesion. Leu-enkephalin (LE) is also found in the SG, however, it is also present in quantity in the ventral horn and central canal areas. Chordotomy has no effect on its distribution indicating LE is intrinsic in the cord and probably contained within interneurons. Morphine increases SP immunoreactivity in the SG, laminae I, IV and V, and in the ventral horn, suggesting morphine analgesia is due to inhibition of intraneuronal SP release in regions specifically associated with pain--SG and lamina V.

References

Sep 29, 1978·Brain Research·N E NaftchiW Schlosser
Feb 25, 1977·Brain Research·V M PickelS E Leeman
Nov 1, 1977·Endocrinology·G MooreK Lederis
Nov 5, 1976·Brain Research·M J BrownsteinS E Leeman
Mar 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L L VaccaK C Hsu
Jun 1, 1975·Canadian Journal of Physiology and Pharmacology·J L HenryM E Morris
Jun 15, 1975·Life Sciences·C B PertS H Snyder
Jun 17, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Dahlström
Feb 21, 1973·Nature: New Biology·D PowellJ T Potts
Mar 9, 1973·Science·C B Pert, S H Snyder
Jul 21, 1971·Nature: New Biology·M M ChangH D Niall
Apr 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L L VaccaN E Naftchi
Apr 1, 1954·The Journal of Comparative Neurology·B REXED
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum
Feb 1, 1976·Neurochemical Research·E J Simon

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Citations

Jan 1, 1990·Annals of the New York Academy of Sciences·N E Naftchi
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N E Naftchi
Apr 1, 1989·British Journal of Pharmacology·J Donnerer
Nov 1, 1982·Peptides·G A OlsonD H Coy

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