Substance P and serotonin mutually reverse their excitatory effects in the rat nucleus tractus solitarius.

Brain Research
T JacquinJ Champagnat

Abstract

Actions and interactions of serotonin and substance P are described in the nucleus tractus solitarius using coronal brainstem slices and intracellular recordings. Substance P (10-100 nM) and serotonin (10-100 microM) applied alone were excitatory, causing depolarization and increasing the input resistance. Reversing effect was obtained using a protocol of long (greater than 5 min) conditioning applications of substance P and shorter (20-60 s) test applications of serotonin: serotonin, which was excitatory by itself during controls, became inhibitory for the steady action potential discharges induced by conditioning substance P applications. In the reverse situation, inhibition was also obtained using prolonged conditioning exposures to serotonin and test applications of substance P. Prolonged conditioning applications (greater than 5 min) were required in these experiments since addition or potentiation, but not inhibition, was found when combining 20-60 s substance P and serotonin applications. In addition to their excitatory effects, substance P and serotonin, applied alone, had another mechanism of action. They reduced the duration of tetraethylammonium-prolonged action potentials. This mechanism was also reversed using cond...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V Chan-PalayS L Palay
Jan 5, 1979·Brain Research·J ChampagnatV Leviel
Apr 30, 1976·Brain Research·E T PierceJ A Hobson
Apr 1, 1986·Pflügers Archiv : European journal of physiology·J ChampagnatD W Richter
Aug 15, 1986·Neuroscience Letters·N LindeforsU Ungerstedt
Nov 8, 1987·The Journal of Comparative Neurology·K B Thor, C J Helke
Mar 1, 1987·Brain Research Bulletin·M A Hashim, D Bieger
Dec 1, 1986·The Journal of Physiology·J ChampagnatK F Shen
Dec 16, 1986·European Journal of Pharmacology·A Shvaloff, R Laguzzi
Nov 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·G Haeusler, R Osterwalder
Jun 1, 1983·British Journal of Pharmacology·P R AdamsS W Jones
Feb 1, 1984·The Journal of Physiology·D E Clapham, E Neher

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Citations

May 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·P D Feldman
Aug 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C S KimE E Lawson
May 2, 2000·Journal of the Autonomic Nervous System·J L SeagardF A Hopp
Aug 28, 1999·Neuroscience Letters·K Ptak, G Hilaire
Feb 4, 1999·Annals of the New York Academy of Sciences·D V SmithB J Davis
Aug 26, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Isabel Martinez-Peña y ValenzuelaR Alberto Travagli
May 12, 2004·Peptides·Cinda J Helke, Jeanne L Seagard
Sep 17, 1993·Brain Research·O RampinM Denavit-Saubié
Feb 27, 2015·Frontiers in Neural Circuits·Daryl P Fields, Gordon S Mitchell
Oct 17, 2002·The Journal of Physiology·Olivier PascualJean Champagnat
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M W Lewis, R A Travagli
Apr 30, 1999·Physiological Reviews·G Hilaire, B Duron
Sep 28, 2000·Journal of Applied Physiology·S Y Zhou, H G Goshgarian
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A Jean

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