PMID: 6165975Jan 1, 1980Paper

Substance P as a baro- and chemoreceptor afferent neurotransmitter: immunocytochemical and neurochemical evidence in the rat

Peptides
C J HelkeD M Jacobowitz

Abstract

The possibility that substances P (SP) is a neurotransmitter of baro- and chemoreceptor afferents in the rat was investigated. SP-like immunoreactivity (SP-I) was analyzed quantitatively by radioimmunoassay in various levels of the nucleus tractus solitarius (NTS), the site of termination of these afferents while SP-containing afferent neurons were studied in various portions of the peripheral pathways by immunocytochemistry. It was found that the NTS contained significant amounts of SP-I and that unilateral removal of the nodose ganglia reduces the SP-I content of those portions of the NTS known to receive vagal afferents. In addition, SP-I was visualized in discrete fibers in the tunica adventitia of the aortic arch and carotid sinus regions, the vagus nerve and nodose ganglia. These results in the rat are consistent with our previous studies in the cat and provide further evidence that SP is contained within baro- and chemoreceptor afferent nerves.

References

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Citations

Aug 27, 1999·Journal of Peptide Science : an Official Publication of the European Peptide Society·M GoetzE J Dufourc
Sep 1, 1995·Journal of Peptide Science : an Official Publication of the European Peptide Society·J GirardieG Precigoux
Jun 10, 2006·Cellular and Molecular Neurobiology·Patrícia Aline Boer, José Antonio Rocha Gontijo
Aug 13, 1982·European Journal of Pharmacology·M Petty, J Reid
May 31, 1982·Life Sciences·S H BuckT F Burks
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·E BarocelliG de Caro
Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
May 1, 1992·Brain Research. Brain Research Reviews·A Randich, G F Gebhart
Jul 1, 1983·Journal of the Autonomic Nervous System·M W Hougland, D B Hoover
Apr 1, 1984·Journal of the Autonomic Nervous System·F Barja, R Mathison
Feb 1, 1985·Journal of the Autonomic Nervous System·P R Howe
Dec 1, 1987·Journal of the Autonomic Nervous System·D S KnightT S Fournet
Aug 1, 1989·Journal of the Autonomic Nervous System·C J Gurusinghe, C Bell
Dec 1, 1989·Journal of the Autonomic Nervous System·J P TernauxP Portalier
Feb 9, 1995·Journal of the Autonomic Nervous System·F MartiniJ J Puizillout
Jun 25, 1995·Journal of the Autonomic Nervous System·J C HardwickR L Parsons

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