Substance P binding in normal neonatal foreskin

The British Journal of Dermatology
P ArenbergerE M Farber

Abstract

The distribution of binding sites for NTE-biotinyl-[Arg3]-substance P (SPB) was demonstrated in neonatal foreskin using a conjugate of streptavidin with horseradish peroxidase. The observed binding is reversible, and may be abrogated by either the non-peptide substance P receptor antagonist, CP-96,345, or by unlabelled substance P. The generalized epidermal distribution and focal dermal localization of SPB binding suggest that although NK-1 receptors are abundant in human neonatal foreskin, neuromodulatory mechanisms may play a significant role in epidermal physiology.

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Citations

Oct 31, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·L MiseryA Claudy
Apr 24, 1999·The British Journal of Dermatology·L MiseryA Claudy
Jun 1, 1997·Photodermatology, Photoimmunology & Photomedicine·J ViacA Claudy

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