PMID: 6165445Jun 15, 1981Paper

Substance P decreases a potassium conductance of spinal cord neurons in cell culture

Brain Research
L M Nowak, R L MacDonald

Abstract

Substance P (SP) produced membrane depolarization and decreased membrane conductance of mouse spinal cord neurons in primary dissociated cell culture. SP-responses were abolished by intracellular tetraethylammonium suggesting that SP decreased potassium conductance. Reversal of SP-responses was not observed with membrane hyperpolarization suggesting that SP reduced a voltage-dependent potassium conductance that was activated by membrane depolarization.

References

Nov 30, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·Y KatayamaJ T Williams
Apr 27, 1979·Brain Research·W Zieglgänsberger, I F Tulloch
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·V Chan-Palay, S L Palay
Mar 15, 1979·The Journal of Comparative Neurology·R P BarberS E Leeman
Feb 1, 1979·Neuropharmacology·N J Dun, A G Karczmar
Jun 4, 1979·Life Sciences·B R Sastry
Oct 1, 1977·Journal of Neurochemistry·A C CuelloL L Iversen
Feb 25, 1977·Brain Research·V M PickelS E Leeman
Nov 5, 1976·Brain Research·M J BrownsteinS E Leeman
Jan 1, 1975·Histochemistry·A G Pearse, J M Polak
Jan 1, 1975·Histochemistry·G NilssonF Sundler
Jun 1, 1975·Canadian Journal of Physiology and Pharmacology·J L HenryM E Morris
Sep 1, 1975·Journal of Neurochemistry·M J DuffyD Powell
Dec 20, 1974·Nature·M Otsuka, S Konishi
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·K Krnjević, M E Morris

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Citations

Feb 22, 2001·Bulletin of Experimental Biology and Medicine·I G Vlasova, A L Dolgopol'skii
Oct 28, 1982·Brain Research·J V Halliwell, P R Adams
Jan 19, 1988·European Journal of Pharmacology·G Reiser, B Hamprecht
May 1, 1992·Journal of the Autonomic Nervous System·S K Agarwal, F R Calaresu
Dec 1, 1982·Regulatory Peptides·G ReiserB Hamprecht
Nov 16, 1982·Neuroscience Letters·A Dray, R D Pinnock
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·N Ogata, H Abe
May 13, 1999·Brain Research. Developmental Brain Research·K PtakR Monteau
Jan 29, 2000·The European Journal of Neuroscience·K PtakR Monteau
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y NakajimaK Yamaguchi
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y De KoninckA C Cuello
Aug 1, 1982·British Journal of Pharmacology·S L Clark, R W Ryall
May 12, 2004·Peptides·Cinda J Helke, Jeanne L Seagard
Apr 24, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C B GundersenI Parker

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