PMID: 2485180Jan 1, 1988Paper

Substance P elicits thromboxane-induced contraction of canine pulmonary veins

Pulmonary Pharmacology
J A Russell

Abstract

The effect of substance P on isolated rings of dog pulmonary vein was examined using tissue bath techniques. Substance P (10(-8)-10(-6) M) had no effect on baseline tone but equally potentiated matched contractions induced by exogenous norepinephrine (NE) and electrical field stimulation (ES). Potentiations produced by substance P were blocked by the substance P antagonist, [D-Arg, D-Pro2, D-Try, Leu] substance P as well as by indomethacin, the thromboxane synthetase inhibitor dazoxiben, and the thromboxane receptor antagonist SQ 29,548. Removal of the endothelium did not alter the substance P potentiation of NE-induced contractions but greatly enhanced the response to exogenous NE. There was marked desensitization to substance P but not to the thromboxane receptor agonist U-46619. We conclude that substance P enhances NE-induced contractions of pulmonary veins by stimulating the production and release of thromboxane A2 from non-endothelial cells. Thromboxane appears to exert a direct effect on smooth muscle cells rather than enhancing NE release from intramural neurons because the responses to NE and ES were potentiated equally. Desensitization probably resulted from down regulation of substance P receptors or depletion of thr...Continue Reading

References

Jan 1, 1986·Annual Review of Physiology·P M VanhoutteD S Houston
Aug 15, 1986·European Journal of Pharmacology·J R Castairs, P J Barnes
Oct 1, 1980·Canadian Journal of Physiology and Pharmacology·R CoutureD Regoli
Nov 1, 1983·Circulation Research·R F Furchgott
Nov 1, 1984·Circulation Research·P J Kadowitz, A L Hyman
Jan 1, 1982·Annals of the New York Academy of Sciences·S I Said

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Citations

Sep 1, 1991·Medicinal Research Reviews·S E Hall
Jan 1, 1991·Pulmonary Pharmacology·J A Russell, J M Roberts
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V Houfflin-DebargeL Storme
Jan 1, 1990·Pulmonary Pharmacology·M Steffan, J A Russell

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