Abstract
Localization of neurokinin 1 receptor (NK1R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart. However, the biological role of SP/NK1R signal pathways in the RA remains unclear. Sprague-Dawley rats were randomly divided into 4 groups (n = 22 each); subjected to sham, ischemia/reperfusion-injury (I/R), I/R with 5 nmole/kg SP injection (SP + I/R), and SP + I/R with 1 mg/kg RP67580 injection (RP, a selective non-peptide tachykinin NK1R antagonist) (RP/SP + I/R). The left anterior descending coronary artery was occluded for 40 min followed by 1 day reperfusion with SP or SP + RP or without either. After 1 day, both atria and ventricles as well as the heart apexes were collected. SP promoted the expression of c-Kit, GATA4, Oct4, Nanog, and Sox2 in only the RA of the SP + I/R rats via NK1R activation. In agreement with these observations, NK1R-expressing c-Kit+ Nkx2.5+GATA4+ cardiac progenitor cells (CPCs) in the ex vivo RA explant outgrowth assay markedly migrated out from RA1 day SP + I/R approximately 2-fold increase more than RA1 day I/R. Treatment of SP promoted proliferation, migration, cardiosphere formation, and potential to differentiate into cardio...Continue Reading
References
Mar 1, 1995·British Journal of Pharmacology·J CulmanT Unger
Sep 12, 2000·Journal of Hematotherapy & Stem Cell Research·Y LiW Ho
Jul 15, 2006·Circulation Research·Natalie GudeMark A Sussman
Sep 25, 2007·Journal of Neurosurgery·Seung-Won ParkRobert J Dempsey
Mar 10, 2009·Nature Medicine·Hyun Sook HongYoungsook Son
Jul 8, 2009·Stem Cells and Development·Shinka MiyamotoHiromi Kurosawa
Dec 20, 2011·Bioconjugate Chemistry·Shahir S RizkAnthony A Kossiakoff
Mar 7, 2012·Circulation·Silvia AmadesiPaolo Madeddu
Mar 31, 2012·ISRN Cardiology·Mani ArsalanJens Garbade
Dec 18, 2014·Tissue Engineering. Part a·Seong-Seo NohByung-Soo Kim
Jan 16, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sachin B MalikJoe Y Hsu
Apr 30, 2015·The Spine Journal : Official Journal of the North American Spine Society·Kyoung-Tae KimSeung-Won Park
Apr 30, 2015·The Journal of Nutrition, Health & Aging·Y ZhouK Tang
Feb 19, 2016·Circulation Research·Peter Paul ZwetslootJoost P G Sluijter
Mar 5, 2016·International Journal of Molecular Medicine·Maria Jose Dubon, Ki-Sook Park
Apr 21, 2016·Development·Maria Paola SantiniJason C Kovacic
Apr 30, 2016·Neural Regeneration Research·Fei-Bin ZhuDe-Ming Liu
Nov 23, 2016·International Journal of Cardiology·Parul DixitRajesh Katare
May 14, 2017·Journal of Cellular Biochemistry·Miguel MuñozAntonio Ayala
Jun 29, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Iolanda AquilaDaniele Torella
Oct 24, 2017·Scientific Reports·Yun-Mi JeongWeon Kim
Dec 15, 2017·Journal of Stem Cell Research & Therapy·Chuan LiAtsushi Amano
Jun 5, 2018·Cell Cycle·Eleonora CianfloneDaniele Torella
Jun 10, 2018·International Journal of Cardiology·Doo Sun SimMyung Ho Jeong
Jul 31, 2018·Frontiers in Physiology·Magdalena Chottova DvorakovaJana Slavikova
Sep 5, 2018·Basic Research in Cardiology·Julia KrauseJustus Stenzig
Nov 13, 2018·Stem Cell Reports·Marta LemmeThomas Eschenhagen
Jan 8, 2019·Annals of Translational Medicine·Daniel A Zuppo, Michael Tsang
Jan 21, 2019·Neuropeptides·Scott P LevickJoseph S Janicki
Feb 28, 2020·Stem Cells International·Yun-Mi JeongWeon Kim