Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines

Experimental and Therapeutic Medicine
Maria Jose Dubon, Ki-Sook Park

Abstract

Due to the therapeutic characteristics of bone marrow (BM)-derived mesenchymal stem cells (MSCs), clinical trials are testing the use of autologous or allogeneic MSCs for the treatment of several conditions. These therapies require large numbers of MSCs and numerous studies are attempting to find substances that could enhance the egression of endogenous MSCs from the BM into the periphery and increase their proliferation in vivo and in vitro. It has been reported that substance P (SP) has the potential to increase the expansion of MSCs in vivo and to induce their mobilization from the BM into the periphery. The aim of the present study was to investigate the effects of SP on the migration and proliferation potential of two BM-derived MSC-like cell lines, ST2 and OP9. SP was found to induce the migration potential of ST2 cells in vitro. Furthermore, SP increased the proliferation of the MSCs cell line, OP9 cell line. Cyclin D1 expression was observed to increase in the OP9 cells, indicating the activation of the cell cycle in response to SP. The upstream signals involved in these phenomena have yet to be elucidated, although previous studies have proposed the activation of the extracellular signal-regulated kinase-1/2 and Wingle...Continue Reading

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Citations

Aug 3, 2017·Journal of Cellular and Molecular Medicine·Xuan LiFa-Ming Chen
Apr 26, 2018·Anti-cancer Agents in Medicinal Chemistry·Miguel Muñoz, Rafael Coveñas
Jan 11, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jihyun UmKi-Sook Park
May 31, 2018·Iranian Journal of Biotechnology·Shakina Yesmin SimuDeok-Chun Yang
Apr 5, 2016·Tissue Engineering and Regenerative Medicine·Jihyun UmKi-Sook Park
Apr 5, 2016·Tissue Engineering and Regenerative Medicine·Nunggum JungKi-Sook Park
May 14, 2017·Journal of Cellular Biochemistry·Miguel MuñozAntonio Ayala
May 12, 2020·Frontiers in Immunology·Dong-Jin KimSang-Ho Lee
Mar 5, 2016·International Journal of Molecular Medicine·Maria Jose Dubon, Ki-Sook Park
Nov 13, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhihong ChenMei Hua Jiang
Mar 27, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Xiao ZhangErica L Scheller

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Methods Mentioned

BETA
electrophoresis
nuclear translocation

Software Mentioned

ImageJ
GraphPad

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