Abstract
Due to the therapeutic characteristics of bone marrow (BM)-derived mesenchymal stem cells (MSCs), clinical trials are testing the use of autologous or allogeneic MSCs for the treatment of several conditions. These therapies require large numbers of MSCs and numerous studies are attempting to find substances that could enhance the egression of endogenous MSCs from the BM into the periphery and increase their proliferation in vivo and in vitro. It has been reported that substance P (SP) has the potential to increase the expansion of MSCs in vivo and to induce their mobilization from the BM into the periphery. The aim of the present study was to investigate the effects of SP on the migration and proliferation potential of two BM-derived MSC-like cell lines, ST2 and OP9. SP was found to induce the migration potential of ST2 cells in vitro. Furthermore, SP increased the proliferation of the MSCs cell line, OP9 cell line. Cyclin D1 expression was observed to increase in the OP9 cells, indicating the activation of the cell cycle in response to SP. The upstream signals involved in these phenomena have yet to be elucidated, although previous studies have proposed the activation of the extracellular signal-regulated kinase-1/2 and Wingle...Continue Reading
References
Jun 22, 1999·Molecular and Cellular Biology·M Hitomi, D W Stacey
Aug 24, 1999·Immunology·J TongA Muraguchi
Jul 6, 2000·Experimental Hematology·A BanfiR Quarto
Jun 25, 2002·The Annals of Thoracic Surgery·Jay G ShakeBradley J Martin
Mar 22, 2003·Current Opinion in Cell Biology·Dennis W Stacey
Dec 23, 2003·Regulatory Peptides·Yao Liang TangM Ian Phillips
Oct 21, 2004·Blood·Sudeepta Aggarwal, Mark F Pittenger
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah C OffleyWade S Kingery
Jun 10, 2008·Current Opinion in Hematology·Louis M Pelus
Jan 9, 2009·Cell Stem Cell·Simon C PitchfordSara M Rankin
Mar 10, 2009·Nature Medicine·Hyun Sook HongYoungsook Son
Jul 28, 2010·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jiao GaoNing Mao
Mar 15, 2011·Best Practice & Research. Clinical Haematology·Maria Ester BernardoFranco Locatelli
Jun 17, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jun DengShi-wu Dong
Dec 24, 2011·Nature Reviews. Immunology·Francois E MercierDavid T Scadden
Mar 27, 2012·Stem Cells International·E Fossett, W S Khan
Jul 19, 2013·The Korean Journal of Internal Medicine·Nayoun Kim, Seok-Goo Cho
Nov 30, 2013·Stem Cells International·Angela BentivegnaGiovanni Tredici
Citations
Aug 3, 2017·Journal of Cellular and Molecular Medicine·Xuan LiFa-Ming Chen
Apr 26, 2018·Anti-cancer Agents in Medicinal Chemistry·Miguel Muñoz, Rafael Coveñas
Jun 3, 2016·In Vitro Cellular & Developmental Biology. Animal·Verónica Castro AceitunoDeok Chun Yang
Jan 11, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jihyun UmKi-Sook Park
May 31, 2018·Iranian Journal of Biotechnology·Shakina Yesmin SimuDeok-Chun Yang
Apr 5, 2016·Tissue Engineering and Regenerative Medicine·Jihyun UmKi-Sook Park
Apr 5, 2016·Tissue Engineering and Regenerative Medicine·Nunggum JungKi-Sook Park
May 14, 2017·Journal of Cellular Biochemistry·Miguel MuñozAntonio Ayala
Feb 19, 2017·Journal of Cellular Physiology·Maria Jose DubonKi-Sook Park
Nov 21, 2018·Frontiers in Neuroscience·Nan ZhangLei Sha
May 12, 2020·Frontiers in Immunology·Dong-Jin KimSang-Ho Lee
Mar 5, 2016·International Journal of Molecular Medicine·Maria Jose Dubon, Ki-Sook Park
Nov 13, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhihong ChenMei Hua Jiang
Mar 27, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Xiao ZhangErica L Scheller