Substance P enhances the release of endogenous serotonin from rat ventral spinal cord.

European Journal of Pharmacology
J FranckE Brodin

Abstract

The effect of the tachykinin neuropeptides, substance P (SP), neurokinin A (NKA) and the neurokinin B (NKB) receptor agonist, senktide, on the potassium-evoked release of endogenous serotonin (5-hydroxytryptamine, 5-HT) was investigated in superfused tissue slices of rat ventral spinal cord, where 5-HT is known to coexist with SP. Endogenous 5-HT was assayed by HPLC with electrochemical detection. The evoked release of 5-HT was significantly enhanced by 10(-4) M SP (190% increase) and 10(-5) M SP (74% increase) but not by 10(-6) M SP, NKA (10(-5) and 10(-4) M) and senktide (10(-5) and 10(-4) M) had no significant effect on the 5-HT release. The results suggest that, in the rat ventral spinal cord, where most of the 5-HT and SP is stored in the same nerve endings. SP but not NKA nor NKB potentiates the evoked release of 5-HT in a dose-dependent manner.

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V Chan-PalayS L Palay
Oct 27, 1987·European Journal of Pharmacology·J A StephensonE Burcher
Nov 19, 1981·European Journal of Pharmacology·R Mitchell, S Fleetwood-Walker
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·C A MarsdenP C Emson

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Citations

Apr 12, 2002·Progress in Neurobiology·A Merighi
Mar 22, 1996·Annals of the New York Academy of Sciences·C J Helke, L Yang
Aug 12, 2009·Journal of Chemical Neuroanatomy·Ruth L Stornetta
Apr 1, 1991·Molecular and Cellular Neurosciences·L A RileyG M Jonakait

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