Substance P-immunoreactive elements in laminae I and II of the chicken spinal cord: a light- and electron-microscopic study.

Neuroscience Research
H Sakamoto, S Atsumi

Abstract

Substance P (SP)-immunoreactive (IR) elements were studied in laminae I and II of the chicken spinal cord in conjunction with an anti-SP monoclonal antibody at light- and electron-microscopic levels by means of the indirect antibody peroxidase-antiperoxidase technique. At the light-microscopic level, SP-IR elements were most intensely observed in the dorsolateral portion of the dorsal horn, laminae I and II. Electron-microscopically, SP-IR boutons contained large spherical dense-cored vesicles (diameter range: 60-125 nm) and spherical clear vesicles. They were subdivided into two groups: large SP-IR boutons, which were the central terminals in synaptic glomeruli, and small SP-IR boutons. In the synaptic glomerulus, two kinds of non-IR presynaptic profiles made axo-axonic synapses with the SP-IR central terminal: one was the presynaptic profile containing pleomorphic clear vesicles and the other was the presynaptic profile containing large dense-cored vesicles. A 'septate junction'-like structure was observed between large SP-IR boutons in synaptic glomeruli. The present results suggest that SP-containing primary afferents are modulated presynaptically by two different neurotransmitter or modulator systems.

References

Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·M Otsuka, S Konishi
Apr 15, 1979·The Journal of Comparative Neurology·H J Ralston
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·V Chan-Palay, S L Palay
Mar 1, 1978·The Journal of Comparative Neurology·A C Cuello, I Kanazawa
Mar 15, 1979·The Journal of Comparative Neurology·R P BarberS E Leeman
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A C CuelloC Milstein
Oct 1, 1977·Journal of Neurochemistry·A C CuelloL L Iversen
Feb 25, 1977·Brain Research·V M PickelS E Leeman
Sep 15, 1975·The Journal of Comparative Neurology·R B Leonard, D H Cohen
Apr 1, 1985·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·S AtsumiT Fujiwara
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S De Biasi, A Rustioni
Feb 19, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S P Hunt, J Rossi
Dec 1, 1987·Neuroscience·J C Holstege, H G Kuypers
May 1, 1972·The Journal of Cell Biology·C Sotelo, R Llinás
Apr 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L L VaccaN E Naftchi
Apr 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V Seybold, R Elde
Jan 1, 1981·Neuroscience·C C LaMotte, N C de Lanerolle

❮ Previous
Next ❯

Citations

Sep 2, 2003·The Journal of Comparative Neurology·Henry C EvrardJacques Balthazart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.