PMID: 6163995Jan 1, 1981Paper

Substance P immunoreactive neurons following neonatal administration of capsaicin

Naunyn-Schmiedeberg's Archives of Pharmacology
A C CuelloF Lembeck

Abstract

Neonatal administration of capsaicin on the days 2, 10 or 20 leads to a long-lasting loss of substance P immunoreactive material in fibers of primary sensory neurons in the spinal cord and medulla oblongata. The degree of depletion examined 6 months after treatment was related to the day of injection. Injections on the second day produced dramatic losses of substance P in fibers of the substantia gelatinosa and the marginal layer of the spinal cord and the spinal nucleus of the trigeminal nerve, although these losses were never complete. The observed depletion of substance P immunoreactive material was homogenous throughout the superficial layers of the dorsal horn and the spinal nucleus of the trigeminal nerve. No changes were observed for the immunoreactivity of Leu-enkephalin in the substantia gelatinosa and the marginal layer of the spinal cord in consecutive sections from the same treated animals. In the medulla oblongata a reduction of substance P immunofluorescent fibers was found in the nucleus tractus solitarii and the spinal nucleus of the trigeminal nerve. Other areas of the central nervous system with a rich innervation of substance P immunoreactive fibers were not affected by capsaicin treatment.

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Citations

Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·L A Chahl
Sep 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H TraurigF Lembeck
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·A HaraK Kisara
Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·G Jancsó, G Such
Jan 1, 1988·Journal of Neural Transmission·A BerggrenU Sillén
May 31, 1982·Life Sciences·S H BuckT F Burks
Jan 1, 1984·Pharmacology & Therapeutics·T Hori
Jan 1, 1988·Pharmacology & Therapeutics·L A Chahl
Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Dec 1, 1984·Brain Research·L C Russell, K J Burchiel
Jan 1, 1988·Peptides·A BjurholmM Schultzberg
Jan 1, 1982·Neurochemistry International·J V PriestleyA C Cuello
Oct 23, 1989·Neuroscience Letters·M Takaki, S Nakayama
Aug 1, 1985·Brain Research Bulletin·G Skofitsch, D M Jacobowitz
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M R Matthews, A C Cuello
May 1, 1990·The Journal of Pharmacy and Pharmacology·M Hajós, G Engberg
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jami L SalomanBrian M Davis
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah C OffleyWade S Kingery

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