Substance P immunoreactivity in the anterior pituitary gland of the guinea pig

Endocrinology
L R DePalatisR Ho

Abstract

The aim of this study was to demonstrate the presence of Substance P (SP) immunoreactive cells within the anterior pituitary gland of the adult guinea pig. By utilizing the PAP technique of Sternberger, immunoreactive SP-containing cells were visualized in all animals studied. These cells were most dense in the ventral portion of the gland. When adjacent tissue sections were incubated with anti-SP serum and anti-rat TSH serum, it was observed that most, if not all, the SP immunoreactive cells examined also exhibited TSH immunoreactivity. However, not all TSH immunoreactive cells contained SP immunoreactivity. Immunoabsorption controls indicated that the immunohistochemical staining reactions were specific for both SP and TSH. The results of this study indicate that immunoreactive SP is present in the guinea pig anterior pituitary and that this peptide is localized within TSH immunoreactive cells.

Citations

Oct 15, 1983·Experientia·J MajorS R Bloom
Nov 15, 1990·Regulatory Peptides·A SeilicovichM C Díaz
Jan 1, 1994·Peptides·H Houben, C Denef
Aug 1, 1989·Molecular and Cellular Endocrinology·P J LarsenT Saermark
Jul 15, 1998·Peptides·G G Nussdorfer, L K Malendowicz
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T AntaklyP Feigelson
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E R BrownJ E Krause
Apr 18, 2003·Thyroid : Official Journal of the American Thyroid Association·Carmen C Pazos-MouraEgberto Gaspar de Moura
Nov 1, 1990·Trends in Endocrinology and Metabolism : TEM·H Houben, C Denef
Aug 28, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E G MouraC C Pazos-Moura
Oct 21, 2000·Endocrine Reviews·J Schwartz
Nov 1, 1990·Journal of Endocrinological Investigation·H HoubenC Denef
Jul 22, 1993·Annals of the New York Academy of Sciences·H S Chowdrey, S L Lightman
Oct 1, 1990·The Journal of Comparative Neurology·P Ciofi, G Tramu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.