PMID: 6162514Feb 2, 1981Paper

Substance P in spinal cord dorsal horn decreases following peripheral nerve injury

Brain Research
D BarbutP D Wall

Abstract

Substance P was located in the spinal cord of rats by immunocytochemistry. Section and ligation of the sciatic nerve produced a depleted area low in substance P in the medial two-thirds of laminae 1 and 2 of segments L4 and 5. The time of depletion began about 5 days after the nerve had been cut and substance P reached a steady minimum by about 9 days and remained depleted for the entire period examined, 31 days. Crush lesions of the sciatic nerve failed to produce the marked and rapid changes of spinal cord substance P observed after section and ligation.

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Citations

Dec 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·H KuwaharaE Munekata
Jan 1, 1985·Journal of Neurology·T Lundeberg
Apr 15, 1985·Experientia·M Kemali, D Gioffré
Sep 1, 1990·Der Schmerz·P Wehling, K P Schulitz
Aug 27, 1993·Brain Research·J M Castro-LopesA Coimbra
Oct 1, 1985·Journal of the Autonomic Nervous System·H Blumberg, W Jänig
May 1, 1983·Regulatory Peptides·V M PickelK K Sumal
Dec 1, 1989·Brain Research. Molecular Brain Research·K NoguchiM Tohyama
Feb 1, 1996·Progress in Neurobiology·P Wilson, P D Kitchener
Jan 2, 1987·Neuroscience Letters·S B McMahon, S Gibson

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