Substance P increases hypothalamic blood flow via an indirect adrenergic-cholinergic interaction

British Journal of Pharmacology
K KlugmanC Rosendorff

Abstract

1 Hypothalamic blood flow (HBF) was measured in conscious rabbits by the 133xenon washout technique. 2 Substance P in a dose of 50 or 500 ng increases HBF while 5 ng is without effect. 3 Cholinoceptor blockade, with either atropine or mecamylamine abolishes the vasodilator effect of substance P. 4 Chemical sympathectomy of the hypothalamus with 6-hydroxydopamine, or adrenoceptor blockade with either propranolol or phenoxybenzamine abolishes the effect of substance P on HBF. 5 Destruction of the intracerebral noradrenergic pathway (INP), or blockade of its vasodilator action, with barbiturate or bicarbonate, likewise prevent the vasodilator action of substance P. 6 These results suggest that substance P may cause an increase in HBF via the release of endogenous acetylcholine, which in turn stimulates the INP.

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Oct 1, 1977·Physiological Reviews·T C Westfall
Mar 15, 1979·The Journal of Comparative Neurology·R P BarberS E Leeman
Jan 1, 1978·Cardiovascular Research·G MitchellC Rosendorff
Feb 1, 1975·Acta Physiologica Scandinavica·D Hallberg, B Pernow
Dec 1, 1969·International Journal of Neuropharmacology·E S JohnsonD W Straughan
Dec 1, 1972·The Journal of Physiology·C D Richards
Apr 25, 1973·Nature: New Biology·P Brawley, E S Johnson
Jul 1, 1971·The Journal of Physiology·W I Cranston, C Rosendorff
Nov 1, 1970·Journal of Applied Physiology·C Rosendorff, R H Luff
Mar 1, 1968·British Journal of Pharmacology and Chemotherapy·G M Maxwell
Apr 1, 1980·Neuroscience Letters·P Holzer, F Lembeck
Sep 1, 1980·Stroke; a Journal of Cerebral Circulation·K P KlugmanC Rosendorff
Jan 1, 1965·Journal of the American Psychoanalytic Association·S GOODMAN
Mar 1, 1965·Acta Physiologica Scandinavica·B LOEFSTROEMJ WAHREN
Feb 15, 1962·The Japanese Journal of Physiology·K KATAOKA
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum

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Citations

Jan 1, 1990·Psychopharmacology·R U HasenöhrlT Schuurman
Dec 1, 1987·Pharmacology, Biochemistry, and Behavior·M S Holzhäuer-OitzlJ P Huston
Jan 1, 1989·Brain Research. Brain Research Reviews·S M Gardiner, T Bennett
Jan 1, 1985·Behavioral and Neural Biology·U Stäubli, J P Huston
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R UddmanF Sundler
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T ItakuraT Maeda
Apr 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R G DaceyM Takayasu
Mar 1, 1983·Stroke; a Journal of Cerebral Circulation·A I Faden
Dec 15, 1983·Nature·S R VincentH C Fibiger

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