PMID: 7541689Apr 1, 1995Paper

Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators

British Journal of Pharmacology
D T WalshS Nourshargh

Abstract

1. The sensory neuropeptide substance P (SP), when released from sensory nerves, has been implicated in the development of neurogenic inflammation. In the present study, using an in vivo model system, we have characterized and investigated the mechanisms underlying SP-induced leukocyte accumulation and oedema formation in the guinea-pig. 2. Intradermally injected SP (i.d., 10(-13) - 10(-9) mol per site), induced a dose- and time-dependent accumulation of 111In-neutrophils, 111In-eosinophils and oedema formation as measured by the local accumulation of i.v. injected 125I-albumin. The leukocyte accumulation evoked by SP was significant at 10(-10) and 10(-9) mol per site, whereas oedema formation was significant at the lowest dose tested (10(-13) mol per site). 3. The NK1 receptor antagonists, CP-96,345 (1 mg kg-1, i.v.) and RP-67,580 (10 micrograms per site, i.d.), significantly attenuated the oedema formation induced by the lower doses of SP. Oedema formation and leukocyte accumulation induced by 10(-9) mol per site SP were unaffected by either antagonist. 4. SP-elicited responses were not significantly affected by the platelet activating factor (PAF) receptor antagonist, UK-74,505 (2.5 mg kg-1, i.v.) or the H1 histamine recepto...Continue Reading

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Citations

Sep 30, 1998·Journal of Neuroscience Research·M BianchiA E Panerai
Jul 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H InoueY Koshihara
Aug 13, 2013·Peptides·Miguel Muñoz, Rafael Coveñas
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Nov 30, 2002·Toxicon : Official Journal of the International Society on Toxinology·Ivani A DesouzaGlaci Ribeiro-DaSilva
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May 1, 2012·TheScientificWorldJournal·Marisa RossoMichael Berger
Mar 8, 2014·World Journal of Gastroenterology : WJG·Miguel Muñoz, Rafael Coveñas
Apr 2, 2003·Journal of Veterinary Pharmacology and Therapeutics·A P Foster, F M Cunningham
Jun 3, 2017·Cutaneous and Ocular Toxicology·Kenji GotoKazuya Ooi
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BoichotV Lagente
Jun 15, 2007·Journal of Leukocyte Biology·Akhil HegdeMadhav Bhatia
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Jan 27, 2015·Inflammation·Stanislava StanojevićMirjana Dimitrijević
Jul 20, 2016·Molecular Medicine Reports·Esra Arslan AydemirKayahan Fişkin
May 13, 2015·Journal of Biosciences·Miguel MunozMaximino Redondo

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