PMID: 7538443Feb 1, 1995Paper

Substance P induces histamine release from human pulmonary mast cells

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Liam G HeaneyM Ennis

Abstract

Substance P elicits histamine release from human skin and rodent mast cells. Since neuropeptide-mediated reflexes may be important in asthma, we examined the ability of substance P to stimulate human mast cells obtained at bronchoalveolar lavage (BAL). BAL samples were obtained at routine bronchoscopy from 35 non-preselected patients. Histamine release experiments were performed in a standard manner using substance P and the calcium ionophore A23187. Both substance P (50 microM) and A23187 caused histamine release (median 26.7% range 6.2-62.8% and 32.1%, 7.7-56.8% respectively) which was significantly greater (P < 0.0001) than the spontaneous release (median 15.6%, range 4.1-33.4%), i.e. that in the absence of any stimulus. Substance P induced histamine release was via an energy dependent process and was blocked by preincubation with antimycin A. A significant correlation was observed between substance P induced release and spontaneous release but was not observed with A23187 induced release. Mast cell counts correlated significantly with substance P induced release but not with spontaneous or A23187 induced release. The substance P induced histamine secretion was elicited at similar concentrations to those used with rodent and...Continue Reading

References

Jan 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N CrimiA Mistretta
Oct 1, 1992·The Journal of Allergy and Clinical Immunology·K NieberG Kunkel
Jan 1, 1990·International Archives of Allergy and Applied Immunology·A F WallsS T Holgate
Jan 1, 1991·Annals of the New York Academy of Sciences·G F Joos, R A Pauwels
Feb 1, 1986·Lancet·P J Barnes
Jan 1, 1986·International Archives of Allergy and Applied Immunology·H AliJ C Foreman
Jan 1, 1987·International Archives of Allergy and Applied Immunology·J BienenstockJ A Denburg
Jan 1, 1987·International Archives of Allergy and Applied Immunology·J C Foreman
Apr 1, 1987·Journal of Applied Physiology·R W FullerP J Barnes
Apr 1, 1989·The Journal of Allergy and Clinical Immunology·K Akagi, R G Townley
Mar 1, 1989·The Journal of Allergy and Clinical Immunology·G F JoosM E Van der Straeten
Sep 1, 1989·Gastroenterology·R H SteadJ Bienenstock
Aug 1, 1988·The American Review of Respiratory Disease·M LavioletteR Coulombe
Oct 1, 1980·British Journal of Pharmacology·M EnnisP M Weston
Sep 1, 1983·Acta Physiologica Scandinavica·J M LundbergA Saria

❮ Previous
Next ❯

Citations

Jul 19, 2006·Journal of Biomedical Science·Ben-Ching LiaoKee-Ching G Jeng
Apr 22, 2005·Current Allergy and Asthma Reports·Christina NassensteinHarald Renz
Mar 26, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V A SpenceJ J F Belch
Nov 8, 2001·European Journal of Pharmacology·H Renz
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·L P A McGarveyJ S Elborn
Apr 27, 2000·Allergy·G F JoosR A Pauwels
Jan 29, 2000·Journal of Veterinary Pharmacology and Therapeutics·B MoreauxP Gustin
Mar 27, 2001·Immunology and Cell Biology·P H Hart
Jun 26, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·A J RiceR Scicchitano
Aug 26, 2010·Cardiovascular Research·Scott P LevickJoseph S Janicki
Sep 13, 2011·Cardiovascular Research·Giselle C MeléndezScott P Levick
Dec 24, 1997·Respirology : Official Journal of the Asian Pacific Society of Respirology·P N ReynoldsR Scicchitano
Oct 12, 2010·Respiratory Research·Stanislas Grassin-DelylePhilippe Devillier
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Tadahide Furuno, Mamoru Nakanishi
Mar 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L J CrossM Ennis
Nov 17, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Peter Bradding, Greer Arthur
Jun 16, 2001·Chest·H A Werner
Apr 10, 2010·Veterinary Immunology and Immunopathology·Anja SipkaHans-Joachim Schuberth
Sep 3, 2008·Microbes and Infection·Sharyn TauroSuresh Mahalingam
Oct 2, 2007·Dermatologic Clinics·Michihiro HideMalcolm W Greaves
Feb 7, 2006·European Journal of Pharmacology·Christina NassensteinArmin Braun
Mar 10, 2007·Biochimica Et Biophysica Acta·Yanlin Jia, Lu-Yuan Lee
Apr 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S C BischoffM Schemann
Mar 27, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L G HeaneyM Ennis
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P Forsythe, M Ennis
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C AdvenierR Pauwels
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P ForsytheM Ennis
Jun 23, 1998·Canadian Journal of Physiology and Pharmacology·H J CookeS A Wolfe
Jul 22, 2006·Biochemical Society Transactions·C NassensteinA Braun
Aug 13, 1999·The American Journal of Physiology·L H MichaelM L Entman
May 1, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S S NatahY T Konttinen
Nov 13, 2003·International Journal of Immunopathology and Pharmacology·A Acharya, V Tripathi
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanneke P M van der KleijJohn Bienenstock
Jan 6, 2021·Current Allergy and Asthma Reports·Monica ThapaliyaHydar Ali
May 5, 2021·Biochemical and Biophysical Research Communications·Naoko SakaiTakanori Ida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.