PMID: 9420137Jan 7, 1998Paper

Substance P is generated in vivo following nasal challenge of allergic individuals with bradykinin

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C R BaumgartenG Kunkel

Abstract

Bradykinin, a potent inflammatory mediator, is released during allergic and non-allergic rhinitis and asthma in man. Nasal bradykinin challenge induces a dose-dependent plasma leakage into the nasal cavity and relevant symptoms of rhinitis. We now report on substance P generation during nasal bradykinin challenge in vivo. The effect of locally applied bradykinin on substance P generation was studied in nine individuals, allergic to grass pollen and six non-allergic controls. In the allergics TAME-esterase activity, histamine and substance P concentrations were measured in nasal lavages and correlated to the clinical symptoms. Substance P concentrations in nasal lavages increased in a dose-dependent fashion during nasal bradykinin challenge in both groups. In the allergic group Substance P-increases correlated with the production of TAME-esterase activity (r = 0.9, P < 0.05) whereas these allergic individuals did not produce any histamine increases. The generation of substance P and the increase of TAME-esterase activity was associated with the onset of clinical symptoms. Correlation of oedema and hypersecretion to substance P were significant by linear regression analysis (r = 0.88, P < 0.005 and r = 0.89, P < 0.02, respectivel...Continue Reading

Citations

Mar 5, 2005·The Journal of Allergy and Clinical Immunology·Peter H HowarthPhilip E Silkoff
Nov 8, 2001·European Journal of Pharmacology·F J HuygenF J Zijlstra
Apr 5, 2003·Toxicology Letters·C van ThrielG A Wiesmüller
Sep 10, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T NabeS Kohno
Jul 5, 2005·Expert Opinion on Investigational Drugs·E M Kudlacz

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