Substance P markedly ameliorates scopolamine-induced impairment of spontaneous alternation performance in the mouse

Brain Research
M UkaiT Kameyama

Abstract

We investigated the effects of intracerebroventricular injection of substance P (SP) on the scopolamine (1 mg/kg)-induced impairment of spontaneous alternation performance in the mouse. SP (0.001-3 micrograms) alone did not influence either spontaneous alternation performance or total arm entries. Scopolamine (1 mg/kg) impaired spontaneous alternation performance accompanied by an increment in total arm entries. In contrast, SP (0.01-1 micrograms) significantly improved the scopolamine (1 mg/kg)-induced impairment of spontaneous alternation performance without influencing the scopolamine (1 mg/kg)-induced increase in total arm entries. The effects of SP (0.1 micrograms) on the scopolamine (1 mg/kg)-induced impairment of spontaneous alternation performance were almost completely reversed by pretreatment with WIN 62577 (1 mg/kg), a tachykinin NK-1 receptor antagonist. These results suggest that SP improves the scopolamine-induced impairment of spontaneous alternation performance through the mediation of tachykinin NK-1 receptors.

References

Jan 24, 1992·Journal of Medicinal Chemistry·B R VenepalliM E Logan
Jan 1, 1990·Psychopharmacology·R U HasenöhrlT Schuurman
Jan 1, 1991·Annual Review of Neuroscience·S Nakanishi
Jan 1, 1980·Progress in Neuro-psychopharmacology·R J Katz, K Schmaltz
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK
Dec 7, 1962·Science·R L ISAACSON, W O WICKELGREN

❮ Previous
Next ❯

Citations

Jun 15, 2007·Psychopharmacology·Judith A SiuciakS McLean
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Robert Lalonde
Apr 4, 2003·Behavioural Brain Research·Andrzej RubajMaria Sieklucka-Dziuba
Jan 16, 1999·Brain Research. Molecular Brain Research·P PompeiC Bertoni-Freddari
Apr 16, 2008·Expert Opinion on Therapeutic Targets·Ahmet Ursavas
Nov 19, 2002·Molecular Pharmacology·S LazarenoN J M Birdsall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.