Substance P modulates taste responses in the nucleus of the solitary tract of the hamster

Neuroreport
B J Davis, David V Smith

Abstract

The effects of substance (SP) microinjections on the electrophysiological response of gustatory neurons within the nucleus of the solitary tract (NST) were examined in hamsters following either anodal electrical or NaCl stimulation of the anterior tongue. For both types of stimulation, SP produced excitatory and suppressive effects on the activity of gustatory NST neurons, with excitatory effects being more common. In response to repetitive anodal stimulation of the tongue, the modulatory effect of SP lasted 30-400 s. In the presence of SP, the firing rate of 48% of the neurons was increased and that of 9% was decreased following NaCl stimulation. This dual action of SP could be due to direct excitation of teste-responsive neurons and to excitation of inhibitory local circuit neurons which, in turn, decrease the responsiveness of gustatory neurons.

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Citations

Jun 16, 2000·Physiology & Behavior·P M Di Lorenzo
Jan 3, 2001·Physiology & Behavior·N J Rutkoski, C W Levenson
Feb 4, 1999·Annals of the New York Academy of Sciences·D V SmithB J Davis
Feb 17, 2000·Annals of the New York Academy of Sciences·M E Smith, F W Flynn
Dec 3, 2003·American Journal of Respiratory and Critical Care Medicine·Jesse P JoadAnn C Bonham
Dec 13, 2006·The Journal of Comparative Neurology·Susan P Travers, Joseph B Travers
Sep 6, 2015·Physiology & Behavior·Jaana M HeinzeSabine Frank
Feb 20, 2003·Brain Research·Cheng-Shu LiDavid V Smith
Jun 14, 2016·The Journal of Comparative Neurology·Jennifer M StratfordThomas E Finger
Oct 24, 2000·The Journal of Comparative Neurology·S P Travers, H Hu
Mar 3, 2006·Behavioral and Cognitive Neuroscience Reviews·Alan C Spector, Susan P Travers
Jun 12, 1998·Japanese Journal of Pharmacology·T YamamotoY Yasoshima
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T MutohJ P Joad
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Chao-Yin ChenAnn C Bonham
May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S A SimonRobert P Erickson

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