Substance P mRNA is present in a population of CGRP-immunoreactive cholinergic postganglionic sympathetic neurons of the cat: evidence from combined in situ hybridization and immunohistochemistry.

Neuroscience Letters
B LindhT Hökfelt

Abstract

A synthetic oligonucleotide probe, complementary to a sequence of the rat beta-preprotachykinin mRNA coding for part of the mature substance P (SP), was used to localize, by in situ hybridization, SP mRNA to individual paravertebral sympathetic ganglion cells of the cat. Subsequent immunohistochemical analysis revealed that most of these neurons contained immunoreactivity to calcitonin gene-related peptide (CGRP), suggesting that they belong to the cholinergic cell population of the scattered type. These cells contain, in addition to SP and CGRP, vasoactive intestinal polypeptide and peptide histidine isoleucine.

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