PMID: 7526299Jul 18, 1994Paper

Substance P released endogenously by high-intensity sensory stimulation potentiates purinergic inhibition of nociceptive dorsal horn neurons induced by peripheral vibration

Neuroscience Letters
Y De KoninckJ L Henry

Abstract

To investigate the interaction at the spinal level of endogenously released substance P with the effects of endogenously released adenosine, extracellular single-unit activity was recorded from dorsal horn neurons in the anesthetized cat. Vibration to the skin inhibited on-going activity of nociceptive neurons; 20 mg/kg caffeine reversibly blocked this inhibition, indicating mediation via adenosine receptors. In half of the cases, this inhibition was potentiated by iontophoretic application of substance P. High-intensity electrical stimulation to a sensory nerve produced excitation which was blocked by an NK-1 (substance P) receptor antagonist, implicating an endogenous neurokinin. When electrical stimulation preceded the vibrational stimulus, the inhibitory effect of vibration was potentiated. Thus, we suggest that endogenous substance P may potentiate the inhibitory response to endogenous adenosine. The results have important implications for integration of inputs from different sensory modalities, especially as they relate to nociception and pain.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Y De Koninck, J L Henry

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Citations

Apr 5, 2003·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ann Gill TaylorFrank E Harrell
May 25, 2006·BMC Complementary and Alternative Medicine·Lisbeth DahlinCarl Molander
Nov 19, 2003·The European Journal of Neuroscience·Sandra M GarrawayLorne M Mendell
Oct 5, 2002·Journal of Neurophysiology·Arturas GrigaliunasCharlotte M Mistretta

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