Substance P stimulates translocation of protein kinase C in brain microvessels.

Biochemical and Biophysical Research Communications
R E CatalánI Fernández

Abstract

The action of substance P on protein kinase C in cerebral microvessels, isolated from bovine, was investigated. We found that in untreated microvessels 85% of the total activity was localized to the cytosolic fraction. Substance P caused a shift of activity to the membrane fraction, accompanied by a loss of activity in the cytosolic fraction. This effect resulted in dose-dependence and it was evident after 5 min treatment. These data suggest that substance P may be involved in the regulation of processes underlying protein phosphorylation in the blood-brain barrier.

References

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Citations

Mar 15, 1991·Experientia·H KobayashiF Izumi
Dec 1, 1993·Molecular and Chemical Neuropathology·O Hanson-PaintonP Grammas
Dec 1, 1993·Neurochemistry International·F Joó
Jan 1, 1996·Neurochemistry International·R Edgardo CatalánF Hernández
Mar 1, 1995·Cellular Signalling·R E CatalánF Hernández
Aug 1, 1996·Cellular Signalling·R E CatalánF Hernández
Nov 12, 2003·Microvascular Research·M Pilar ColladoR Edgardo Catalán
Aug 26, 2003·Advanced Drug Delivery Reviews·Anne M WolkaThomas P Davis
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R E CatalánG Díaz
Jan 1, 1992·Journal of Neurochemistry·F Joó
Jan 4, 2012·Journal of Pharmaceutical Sciences·Pooja Naik, Luca Cucullo
Dec 8, 2004·Journal of Neuroimmunology·Wen-Zhe Ho, Steven D Douglas
May 27, 2003·CNS Spectrums·Wen-Zhe HoSteven D Douglas
Jun 1, 1996·Neuroscience Research·R E CatalánF Hernández
Oct 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Hyslop, G De Nucci

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