PMID: 6160175Mar 1, 1980Paper

Substance P, VIP, enkephalin and somatostatin immunoreactive neurons in intestinal tissue transplanted to the anterior eye chamber

Journal of the Autonomic Nervous System
M SchultzbergS Said

Abstract

Tissue pieces of small and large intestine from pre- and postnatal and adult rats, respectively, were transplanted to the anterior eye chamber of the rat. Immunohistochemical studies revealed high numbers of substance P-, vasoactive intestinal polypeptide (VIP)- and enkephalin-containing nerve fibers, especially in the circular smooth muscle layer and in the myenteric plexus of the intestinal tissue transplants. A small number of somatostatin-containing fibers were observed. The distribution patterns of the various peptide-containing neurons in the grafts resembled those which have been described in the intact gastro-intestinal wall. Substance P, VIP, enkephalin and somato-statin immunoreactive fibers were seen also in the host irides. No obvious differences in peptide innervation in grafts and host irides were observed between normal and sympathectomized animals and animals lesioned in the trigeminal ganglion. These findings suggest that most of the peptide-containing fibers in the intestinal transplants and the host irides originate in the transplanted tissue. Thus, it is shown that peptide neurons can survive in this transplantation model, which may be useful for functional studies of intestinal physiology including peptider...Continue Reading

References

Jul 12, 1979·Nature·J AlumetsR Uddman
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
May 28, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R FrancoJ B Furness
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L I LarssonJ R Rehfeld
Jan 1, 1975·Histochemistry·A G Pearse, J M Polak
Jan 1, 1975·Histochemistry·G NilssonF Sundler
Aug 1, 1975·Acta Physiologica Scandinavica·G NilssonK Folkers
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B K HartmanS Udenfriend
Jul 21, 1971·Nature: New Biology·M M ChangH D Niall
Nov 8, 1958·Nature·C C CURTAIN
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltR Luft
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum
Nov 1, 1977·Neuroscience Letters·M CostaA Arimura

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Citations

Aug 8, 1983·Life Sciences·R B MurrayA D Korczyn
Jan 1, 1989·Pharmacology & Therapeutics·J Fahrenkrug
Oct 1, 1980·Journal of the Autonomic Nervous System·M Alund, L Olson
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C S Ayer-LeLievre, A Seiger
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C Ayer-LeLievre, A Seiger
Jun 1, 1993·Pharmacology & Toxicology·J Fahrenkrug
Aug 1, 1982·Acta Physiologica Scandinavica·S LeanderR Uddman
Apr 23, 1997·European Journal of Pharmacology·A R GintzlerL Wang

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