Substance use in individuals at clinical high risk of psychosis.

Psychological Medicine
Lisa BuchyJean Addington

Abstract

A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between substance use and later transition to psychosis in CHR individuals are mixed. At baseline and 6- and 12-month follow-ups, 735 CHR and 278 control participants completed the Alcohol and Drug Use Scale and a cannabis use questionnaire. The longitudinal trajectory of substance use was evaluated with linear mixed models. CHR participants endorsed significantly higher cannabis and tobacco use severity, and lower alcohol use severity, at baseline and over a 1-year period compared with controls. CHR youth had higher lifetime prevalence and frequency of cannabis, and were significantly younger upon first use, and were more likely to use alone and during the day. Baseline substance use did not differentiate participants who later transitioned to psychosis (n = 90) from those who did not transition (n = 272). Controls had lower tobacco use than CHR participants with a prodromal progression clinical outcome and lower cannabis use than th...Continue Reading

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Citations

Jun 13, 2016·Psychiatry Research. Neuroimaging·Lisa BuchyJean Addington
Dec 5, 2019·Social Psychiatry and Psychiatric Epidemiology·Megan S FarrisJean Addington
Dec 20, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·P Fusar-PoliP McGuire
Jun 6, 2020·Early Intervention in Psychiatry·Megan S FarrisJean Addington
Nov 18, 2018·The International Journal of Social Psychiatry·María Bettina Ortiz-MedinaCarlos Roncero
Dec 6, 2018·Frontiers in Psychiatry·James G ScottAntti Mustonen
May 25, 2021·Psychiatry Research·Daniel MamahDavid M Ndetei

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