Substantia nigra lesions attenuate the development of hypertension and behavioural hyperreactivity in spontaneously hypertensive rats

Pharmacology, Biochemistry, and Behavior
M van den BuuseW De Jong

Abstract

The possible relation between changes in behaviour and the development of hypertension was investigated. Depletion of striatal dopamine by lesions in the substantia nigra of Spontaneously Hypertensive Rats (SHR) was associated with an inhibition of the development of hypertension. In the open field a decrease in rearing score was found with no effect on other parameters. Rearing activity was significantly correlated with blood pressure as well as with striatal dopamine content. Blood pressure was weakly, although significantly, correlated with striatal dopamine content. Neither blood pressure nor striatal dopamine content was significantly correlated with ambulation activity. In normotensive Wistar-Kyoto rats a decrease was also found in rearing activity after nigra lesions, although this effect was less pronounced. Antihypertensive treatment of SHR with captopril or hydralazine did neither affect striatal dopamine levels nor open-field behaviour. Induction of renal hypertension or DOCA-salt hypertension in Wistar rats did not influence brain dopamine or behaviour. The results support the suggestion that brain dopamine systems may play a role in the development of hypertension in SHR as well as in the changes in behaviour obser...Continue Reading

References

Oct 1, 1979·Behavioral and Neural Biology·S Knardahl, T Sagvolden
Apr 1, 1975·Circulation Research·J P Chalmers
Apr 30, 1976·Brain Research·J Van der GugtenD H Versteeg
Jan 1, 1986·Pharmacology, Biochemistry, and Behavior·M Van den BuuseW de Jong
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Apr 1, 1974·Acta Physiologica Scandinavica·M Hallbäck, B Folkow
Jan 1, 1972·Neuroendocrinology·W H GispenE R de Kloet
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J M Sitsen, W de Jong
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·A HäuslerU H Otten
Nov 1, 1984·Hypertension·M van den BuuseW de Jong
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·H KawabeT Saruta
Mar 1, 1983·Hypertension·E D HendleyD Whitehorn
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·D C Tucker, A K Johnson
Apr 1, 1982·Behavioral and Neural Biology·R McCarty, R F Kirby
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

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Citations

Jun 1, 1987·Neuroscience Letters·M van den Buuse, W de Jong
Feb 19, 1997·European Journal of Pharmacology·K TsudaY Masuyama
Dec 4, 2004·Behavioural Pharmacology·M B CalzavaraR Frussa-Filho
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M van den Buuse, W de Jong
Mar 22, 1988·Brain Research·N AlexanderC K Haun

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