Substantia nigra stimulation evoked antidromic responses in rat neostriatum

Experimental Brain Research
L J RyanP M Groves

Abstract

Electrical stimulation of the substantia nigra of rats elicits a burst of small amplitude waves with a latency of 4-6 ms that may last for 10-15 ms throughout much of the neostriatum. Frontal cortex stimulation also elicits a burst response, which can occlude the substantia nigra response. The substantia nigra evoked burst response was still present after chronic neocortical ablation or thalamic transection or both treatments combined. The response corresponds to the first sharp negative wave of the substantia nigra evoked neostriatal field potential. Single substantia nigra evoked action potentials were recorded in neostriatum with a mean latency of 9.8 ms, ranging from 4-22 ms. These action potentials were considered to be antidromic because they were occluded during appropriate collision intervals by orthodromic action potentials elicited by frontal cortex stimulation. Subthreshold frontal cortex conditioning stimulation did not alter the threshold for activation from substantia nigra. The refractory period for the axon was at least as long as that for the soma and ranged between 0.8-2.0 ms. The antidromic responses failed to follow low frequency stimulation (less than 40 Hz for 3000 ms). This failure occurred in the axon be...Continue Reading

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Related Concepts

Adrenal Cortex Diseases
Globus Pallidus
Thalamic Nuclei
Neostriatum
Reaction Time
August Rats
Paleostriatum
Neurons
Action Potentials
Lentiform Nucleus Structure

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