Substantial Decline in Prevalence of Vaccine-Type and Nonvaccine-Type Human Papillomavirus (HPV) in Vaccinated and Unvaccinated Girls 5 Years After Implementing HPV Vaccine in Norway

The Journal of Infectious Diseases
Berit FeiringLill Trogstad

Abstract

In 2009, quadrivalent human papillomavirus (HPV) vaccine was introduced in a school-based single-cohort program targeting 12-year-old girls in Norway. We estimated the impact of the Norwegian HPV immunization program. Three birth cohorts of 17-year-old girls, 2 nonvaccine-eligible cohorts (born 1994 or 1996) and 1 vaccine-eligible cohort (born 1997) were invited to deliver urine samples. The samples were analyzed for 37 HPV genotypes. HPV prevalence was compared between birth cohorts and between vaccinated and unvaccinated girls within and across birth cohorts after linkage to the Norwegian Immunisation Registry. In total, 17749 urine samples were analyzed. A 42% (95% confidence interval [CI], 37%-47%) reduction in any HPV type and 81% (95% CI, 76%-85%) reduction in vaccine types (HPV-6/11/16/18) were observed in the vaccine-eligible cohort compared to the 1994 cohort. Vaccine types were reduced by 54% (95% CI, 39%-66%) and 90% (95% CI, 86%-92%) in unvaccinated and vaccinated girls, respectively, from the 1997 cohort, compared with unvaccinated girls born in 1994. A significant reduction was also observed for several nonvaccine types. Vaccine-type prevalence was reduced by 77% (95% CI, 65%-85%) in vaccinated compared with unvac...Continue Reading

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Citations

Sep 15, 2019·Expert Review of Anti-infective Therapy·Jade PattynAlex Vorsters
Jun 24, 2020·Vaccines·Laila KhawarRebecca J Guy
Oct 18, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Cyra PatelHelen Marshall
Nov 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joske HoesUNKNOWN Medical Microbiological Laboratories and Public Health Services
Jun 19, 2021·Journal of Pediatric and Adolescent Gynecology·Delphine GallantMireille Merckx
Feb 2, 2022·Human Vaccines & Immunotherapeutics·Alexander Pedroza-GonzalezGlustein Pozo-Molina

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Methods Mentioned

BETA
urine sampling
genotyping
PCR

Software Mentioned

Stata
SE

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